Method for treating neurological disorders

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes

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A61K 9127

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active

055760180

ABSTRACT:
A method for ameliorating a neurological disorder in a human by administration to the cerebrospinal fluid (CSF) of a therapeutic agent in a dispersion system which allows the therapeutic agent to persist in the cerebro-ventricular space.

REFERENCES:
patent: 4078052 (1978-03-01), Papahadjopoulos
patent: 4089801 (1978-05-01), Schneider
patent: 4145410 (1979-05-01), Sears
patent: 4224179 (1980-09-01), Schneider
patent: 4235871 (1980-11-01), Papahadjopoulos et al.
patent: 4310506 (1982-01-01), Baldeschwieler et al.
patent: 4394372 (1983-07-01), Taylor
patent: 4522803 (1985-06-01), Lenk et al.
patent: 4588578 (1986-05-01), Fountain et al.
patent: 4599227 (1986-07-01), Dees et al.
patent: 4610868 (1986-09-01), Fountain et al.
patent: 4619913 (1986-11-01), Luck et al.
patent: 4752425 (1988-07-01), Martin et al.
patent: 4769250 (1988-09-01), Forssen
patent: 4781871 (1988-11-01), West, III et al.
patent: 4813399 (1989-03-01), Gordon
patent: 4920016 (1990-04-01), Allen et al.
patent: 5000959 (1991-03-01), Iga et al.
patent: 5021200 (1991-06-01), Vanlerberghe et al.
patent: 5077056 (1991-12-01), Bally et al.
patent: 5204112 (1993-04-01), Hope et al.
patent: 5211955 (1993-05-01), Legros et al.
patent: 5225212 (1993-07-01), Martin et al.
Huang, Biochemistry, 8:334-352, 1969, "Studies on Phosphatidylcholine vesicles formation and Physical characteristics."
Bang, M. Mol. Bio., 13-238-252, 1965, "Diffusion of univalent ions across the lamellae of swollen phospholipids."
Szoka, et al., Ann. Rev. Biophys, Bioeng., 9:465-508, 1980, "Comparative properties and methods of preparation of lipid vesicles (liposomes)."
Shakiba, et al., Investigative ophthalmology and visual Science, 34(10):2903 10, 1993 Sep., "Evaluation of retinal toxicity and liposome encapsulation of Anti-CMV Drug 2'-nor-cyclic GMP."
Frucht-Perry, et al., Cornea, 11(5):393-7, 1992 Sep., "Fibrin-enmeshed tobramycin liposomes: single application topical therapy of pseudomonas . . . ".
Assil, et al., Investigative Ophthalmology and Visual Science, 32(13):3216-20 1991 Dec., "Tobramycin liposomes. Single subconjunctival therapy of . . . ".
Assil, et al., Investigative Ophthalmology and Visual Science, 32(11):2891-7, 1991 Oct., Liposome suppression of proliferative vitreoretinopathy. Rabbit..
Turski, et al., Magnetic Resonance in Medicine, 7(2):184-96, 1988 Jun., "Magnetic resonance imaging of rabbit brain after intracarotid injection . . . ".
Skuta, et al., American Journal of Ophthalmology, 103(5): 714-16, 1987, May 15 "Filtering surgery in owl monkeys treated with the antimetabolitc . . . ".
Assil, et al., Archives of Ophthalmology, 105(3):400-3, 1987 Mar., "Multivesicular liposomes. Sustained release of the antimetabolite . . . ".
Barbet, et al., Biochimica et Biophysica Acta, 772(3):347-356, 1984, May 30, "Weat acid-induced release of liposome-encapsulated carboxyfluorescein".
Kim, et al., Biochim. Biophys. Acta, 646:1, 1981, "Preparation of cell-size unilamellar liposomes with high captured volume and defined size . . . ".
Kim, et al., Biochim. Biophys. Acta, 728:339-348, 1983, "Preparation of multivesicular liposomes".
Kim, et al., Biochim. Biophys. Acta, 793:801, 1985, "Preparation of multilamellar vesicles of defined size-distribution by solvent-spherule . . . ".
Kim, et al., Cancer Treat. Rep., 71:705-711, 1987, "Multivesicular liposomes containing cytarabine entrapped in the presence of . . . ".
Kim, et al., Cancer Research, 47:3935-3937, 1987, "Multivesicular Liposomes Containing cytosine arabinoside for slow-release intrathecal therapy."
Kim, et al., Cancer Treat. Rep., 71:447-450, 1987, "Multivesicular liposomes containing cytosine arabinoside for slow-release . . . ".
Bonetti, et al., Cancer Chemotherapy and Pharmacology, In Press, 1993, "An extended-release formulation of methotrexate for subcutaneous . . . ".
Kim, et al., Cancer Res., 53:1596-1598, 1993, "Prolongation of drug action in CSF by encapsulation into multivesicular liposomes."
Kim, et al., Cancer Chemother Pharmacology, 19:307-310, 1987, "Modulation of the peritoneal clearance of liposomal ara-C by blank liposomes."
Roy, et al., Cancer Chemother, Pharm., 28:105-108, 1991, "Multivesicular liposomes containing bleomycin for subcutaneous administration."
Kim, et al., Reg. Cancer Treat., 2:170-173, 1989, "Intratumoral chemotherapy with multivesicular liposomes containing 1-b-D-arabino . . . ".
Kim, et al., J. Inf. Dis., 162:750-752, 1990, "Multivesicular liposomes for CSF delivery of retroviral agent DDC."
Chamberlain, et al., Archives of Neurol, 50(3):261-264, 1993, "Treatment of leptomeningeal metastasis with intraventricular administration of . . . ".
Chatelut, et al., Cancer Them. Pharmacol., 32:179-182, 1993, "A slow-release methotrexate formulation for inrathecal chemotherapy."
Russack, et al., Ann. Neurol., 34:108-112, 1993, "Quantitative cerebrospinal fluid cytology in patients receiving intracavitary chemotherapy."
Kim, et al., J. Clin. Oncol., 11:2186-2193, 1993, "Extended cerebrospinal-fluid cytarabine exposure following intrathecal administration of DTC 101."
Kim, Drugs, 46:618-638, 1993, "Liposomes as carriers of cancer chemotherapy: a review."
Kim, Kim, Kim, Cancer Chemother. Pharmacol., 33:187-190, 1993, "Extended-release formulation of morphine for subcutaneous administration. "
Ishii, Liposome Technology, 1:111-121, 1993, "Production and Size Control of large unilamellar liposomes by emulsification".
Cullis, et al., Phospholipids and Cellular Regulation, 1:65-123, 1985, "Structural properties and functional roles of phospholipids in . . . ".

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