Method for treating neurocardiogenic syncope

Surgery – Miscellaneous – Methods

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514220, 514338, A61B 1900

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active

057068291

ABSTRACT:
The present invention relates to methods for treating neurocardiogenic syncope. The method involves administering to a patient an effective amount of a compound having the formula: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.5 are each selected from the group consisting of hydrogen and lower alkyl; and R.sub.3 and R.sub.4 are each selected from the group consisting of hydrogen, halogen, lower alkyl, nitro, amino, trifluoromethyl, and lower acylamino; at least one of R.sub.3 and R.sub.4 being a nitrogen containing group,
or a pharmaceutically acceptable salt thereof.

REFERENCES:
patent: 3116203 (1963-12-01), Kariss et al.
patent: 3121114 (1964-02-01), Keller et al.
patent: 3123529 (1964-03-01), Kariss et al.
patent: 3203990 (1965-08-01), Keller et al.
patent: 3335181 (1967-08-01), Focella et al.
patent: 4472397 (1984-09-01), Lahti et al.
patent: 4772599 (1988-09-01), Watjen
patent: 5284491 (1994-02-01), Sutton et al.
patent: 5302715 (1994-04-01), Buechler et al.
patent: 5317018 (1994-05-01), Walser et al.
patent: 5409946 (1995-04-01), Garvey et al.
patent: 5501701 (1996-03-01), Markowitz et al.
Goodman and Gilman, "The Pharmacological Basis of Therapeutics" fourth edition. pp. 177-181, 1970.
Sugimoto, et al. "The effects of diazepam on rat isolated heart muscle." Clinical and Experimental Pharmacology and Physiology. 5:655-663, 1978.
Defeudis, F.V. "GABA and `neuro-cardiovascular` mechanisms." Neurochemistry International. 3(2): 113-121, 1981.
Petersdorf, et al, eds. "Harrison's Principles of Internal Medicine." 1983. pp: 76-80, 1298, 2025-2027, 2106, 1983.
Raza, et al. "Comparison of the hemodynamic effects of midazolam and diazepam in patients with coronary occlusion." International Journal of Clinical Pharmacology, Therapy and Toxicology, 27(Jan. 1989): 1-6, 1989.
Osman, et al. "Dose-dependent effects of intravenous alprazolam on neuroendocrine, biochemical, cardiovascular, and behavioral parameters in humans." Psychopharmacology. 111:295-300, 1993.
Abi-Samra et al., Pacing Clin Electrophysiol 11(8): 1202-1214 (1988).
Fitzpatrick et al., Pacing Clin Electrophysiol 13(5): 619-624 (1991).
Kapoor, JAMA 268(18): 2553-2560 (1992).
Kenny et al., Lancet 1(8494): 1352-1355 (1986).
Kosinski et al., Pacing Clin Electrophysiol 18(4 Pt 1): 716-724 (1995).
Lipton and Forstater, J Emerg Med 11(6): 723-727 (1993).
Milstein et al., Am J Cardiol 65(20): 1339-1344 (1990).
Natale et al., Pacing Clin Electrophysiol 18(4 Pt 1): 655-662 (1995).
Sra et al., Cardiol Clin 11(1): 183-191 (1993).
Sra et al., N Engl J Med 328(15): 1085-1090 (1993).
Sternbach et al., J Med Chem 6:261-265 (1963).
Sato and Malow, in Antiepileptic Drugs, 4th Edition, edited by R.H. Levy et al., Raven Press, Ltd., New York, pp. 725-734 (1995).
The Merch Index, 10th Edition, edited by W. Windholz et al., Merck & Co., Inc., Rahway, New Jersey, p. 2351 #2352 (1983).
The Physicians' Desk Reference, 39th Edition, publisher E.R. Barnhart, Medical Economics Company Inc., Oradell, New Jersey pp. 429, 1680-1681 (1985).
Kadri et al., Abstract from the 17th Annual Meeting of the North American Society of Pacing and Electrophysiology, published Apr. 1996.

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