Method for treating nerve injury pain associated with shingles (

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Web – sheet or filament bases; compositions of bandages; or...

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514887, 514944, 514969, 424443, A61K 970, A61K 906

Patent

active

054117380

ABSTRACT:
Methods and compositions are offered for reducing nerve injury pain associated with shingles (herpes-zoster and post-herpetic neuralgia), where intradermal delivery of lidocaine is maintained for a predetermined period of time. The lidocaine appears to specifically affect the damaged nerve fibers, while leaving the undamaged and normal nerve fibers with retention of response to other stimuli. Lidocaine formulations are provided which allow for the necessary dosage of the lidocaine in the dermis during the period of treatment. The formulation may be covered with an occlusive or non-occlusive dressing, which protects the lidocaine formulation from mechanical removal and enhances the transport of the lidocaine into the dermis. Long term relief is realized after maintenance of the administration of lidocaine has been terminated.

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Rowbotham MC. Topical lidocaine gel relieves postherpetic neuralgia. Ann Neurol 1994; 36:716-723.
King, "Concerning the Management of Pain Associated with Herpes Zoster and of Postherpetic Neuralgia,"Pain (1988) 33:73- 78.
Ostrenga et al., "Significance of Vehicle Composition I: Relationship Between Topical Vehicle Composition, Skin, Penetrability and Clinical Efficacy," J. Pharmaceutical Sciences (971) 60:1175-1179.
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Rowbotham & Fields, "Topical Lidocaine Reduces Pain in Post-Herpetic Neuralgia," Pain (1989) 38:297-301.

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