Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-07-03
2007-07-03
Henley, III, Raymond J. (Department: 1614)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S411000, C514S578000
Reexamination Certificate
active
10919473
ABSTRACT:
An object of the present invention is to provide a method which is able to prevent or improve the progress of myolytic diseases such as muscular dystrophy. Such an object is able to be solved by a method where an effective dose of an inhibitor for hematopoietic prostaglandin D synthase (H-PGDS) or an antagonist to prostaglandin D receptor is administered to a patient who needs it. The present invention also provides a method for screening compounds which are able to prevent the progress of myolytic diseases and to improve it using human H-PGDS overexpressed transgenic mice.
REFERENCES:
patent: 2005/0227984 (2005-10-01), Urade et al.
Cumming et al, Acta Neurophathol Suppl (Berl), 7:305-307, 1981.
Okinaga et al, Acta Neuropathology, 104:377-384, 2002.
Eguchi et al, Proceedings of the National Academy of Science, 94:14689-14694, 1997.
Urade et al, Prostaglandins and Other Lipid Mediators, 68-69:375-382, 2002.
Sato et al., “Prevention of Muscular Necrosis By inhibition of hematopoietic prostaglandin D synthase” Program and Abstracts of the 76thAnnual Meeting of the Japanese Biochemical Society, Japan 75:(8), 4P-074, Aug. 25, 2003.
Yo Sato et al., “Prevention of muscular necrosis by inhibition of hematopoietic prostaglandin D synthase”, (2004), Neuroscience Research, vol. 50, abstract only.
Aritake Kosuke
Eguchi Naomi
Miyano Masashi
Mori Ikuko
Sato Yo
Browdy and Neimark PLLC
Henley III Raymond J.
Osaka Bioscience Institute
Riken
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