Drug – bio-affecting and body treating compositions – Lymphokine
Patent
1995-03-30
1998-06-16
Spector, Lorraine M.
Drug, bio-affecting and body treating compositions
Lymphokine
530351, 530402, 930140, 435 695, A61K 3819, C07K 1113, C07K 1452
Patent
active
057665818
ABSTRACT:
Disclosed are novel proteins, referred to as megakaryocyte growth and development factors (MGDFs; also generally referred to as Mpl ligands), that have a biological activity of stimulating the growth of megakaryocytes and augmenting the differentiation or maturation of megakaryocytes, ultimately to result in the production of platelets. MGDF derivatives comprising MGDF molecules attached to water soluble polymers, such as polyethylene glycol, are also disclosed, along with methods for their preparation. The MGDF proteins and derivatives are useful in methods for treating mammals to increase platelets and/or megakaryocytes. Also disclosed are processes for obtaining the MGDFs in homogeneous form from natural sources and producing them by recombinant genetic engineering techniques from mammals, including humans.
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Bartley Timothy D.
Bogenberger Jakob M.
Bosselman Robert A.
Hunt Pamela
Kinstler Olaf B.
Amgen Inc.
Cook Robert R.
Levy Ron K.
Odre Steven M.
Spector Lorraine M.
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