Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,...
Patent
1996-08-05
1998-03-24
Walsh, Stephen
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
4241421, 4241451, 4241581, 53038824, 53038823, 530350, 514 2, 514 8, A61K 39395, A61K 3818, A61K 3843, C07K 1624
Patent
active
057309760
ABSTRACT:
There is disclosed a method of treating a mammal infected with a macrophage pathogen comprising administering an effective amount of a TGF-.beta. antagonist. Macrophage pathogens include any pathogenic microorganism that replicates within macrophage cell hosts as their exclusive or primary host cells. TGF-.beta. antagonists include blocking antibodies specific for a human TGF-.beta., soluble TGF-.beta. receptors, protease inhibitors that inactivate a protease responsible for activating a precursor TGF-.beta. into an active, mature TGF-.beta., and combinations thereof.
REFERENCES:
patent: 5543143 (1996-08-01), Reed
Sher, A., et al (Immunological Reviews 127,183), 1992.
Zhou, D., et al., (FASEB J. 5,2582), 1991.
Geissler R. G., et al. (Ann. Hematology 62,151), 1991.
Arteaga et al., "Anti-Transforming Growth Factor (TGF)-.beta. Antibodies Inhibit Breast Cancer Cell Tumorigenicity and Increase Mouse Spleen Natural Killer Cell Activity," J. Clin. Invest. 92: 2569-2576, 1993.
Corixa Corporation
Ranjan Mukul
Walsh Stephen
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