Method for treating LPS-mediated disorders

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

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536 172, 536 179, 536 187, 536 55, 53612313, A61K 3170, C07H 304, C07H 306, C07H 506

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active

056483430

ABSTRACT:
A purified lipid A from Rhizobium leguminosarum biovar phaseoli CE3, as well as analogs and derivatives of the purified lipid A are provided. Compositions containing heterogenous mixtures of lipid A from R. leguminosarum bv. phaseoli CE3 are also provided. The lipid A provided herein can be combined with a pharmaceutically acceptable carrier. Methods of stimulating the immune system in a subject, treating or preventing toxic shock in a subject, and methods of treating and preventing a lipopolysaccharide mediated disorder in a subject using the novel lipid A are provided.

REFERENCES:
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Carlson et al., "The Rhizobiaceae lipopolysaccharides (LPSs)," Abstract, 5th International Symposium on the Molecular Genetics of Plant-Microbe Interactions, Sep. 9-14, 1990.
Hollingsworth & Carlson, "27-Hydroxyoctacosanoic Acid Is a Major Structural Fatty Acyl Component of the Lipopolysaccharide of Rhizobium trifolii ANU 843," The Journal of Biological Chemistry, 264:9300-9303 (1989).
Bhat & Carlson, "Structure of a Galacturonic Acid Containing Lipid A from Rhizobium phaseoli CE3," Abstract, The First Congress of the International Endotoxin Society, May 10-12, 1990.
Carlson, et al., "Rhizobium lipopolysaccharides: Their structures and evidence for their importance in the nitrogen-fixing symbiotic infection of their host legumes," Biochemical and Genetic Analysis of Gene Expression in Plants and Bacteria, Chapman and Hall, New York, London (1991).
Bhat, et al., "Distribution and Phylogenetic Significance of 27-Hydroxy-Octacosanoic Acid in Lipopolysaccharides form Bacteria Belonging to the Alpha-2 Subgroup of Proteobacteria," International Journal of systematic Bacteriology, 41:213-217 (Apr. 1991).
Bhat, et al., "Occurrence of Lipid A Variants with 27-Hydroxyoctacosanoic Acid in Lipopolysaccharides form Members of the Family Rhizobiaceae," Journal of Bacteriology, 173:2155-2159 (Apr. 1991).
Bhat & Carlson, "A New Method for the Analysis of Amide Rhizobiaceae," Journal of Cellular Biochemistry, Supplement 16D (1992), Keystone Symposia on Molecular & Cellular Biology, Mar. 5-27, 1992.
Carlson, et al., "Rhizobium lipopolysaccharides; their structures and evidence for their importance in the nitrogen-fixing symbiotic infection of their host legumes," Plant Biotechnology and Development, Chapter 5, pp. 33-44, CRC Press (1992).
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