Method for treating leukemias

Details Method for treating leukemias Method for treating leukemias

1992-08-05

1993-09-21

Rollins, John W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 232, 435 691, 4351723, 4353201, A61A 3170, C07H 1700, C12P 2106, C12N 1500

Patent

active

052469212

ABSTRACT:
A novel ribozyme, capable of selectively cleaving the bcr-abl mRNA of a cell containing the Philadelphia Chromosome, thereby blocking synthesis of BCR-ABL protein is provided. Methods for using the ribozyme for treating leukemia patients and methods of producing the ribozymes are also provided.

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patent: 5093246 (1992-03-01), Cech et al.
patent: 5116742 (1992-05-01), Cech et al.
N. Sarver et al, Science, 247:1222-1225 (1990).
J. Haseloff et al, Nature, 334:585-591 (1988).
D. E. Ruffner et al, Gene, 82:31-41 (1989).
M. Koizumi et al. FEBS Letters, 239(2):285-288 (1988).

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