Method for treating Kawasaki syndrome by administration of an an

Details Method for treating Kawasaki syndrome by administration of an an Method for treating Kawasaki syndrome by administration of an an

1993-04-05

1995-10-24

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

4241651, 514192, 514200, A61K 3940, A61K 3943, A61K 3174, A61K 31545, A61K 31675

Patent

active

054608139

ABSTRACT:
The invention relates to various methodologies for diagnosing Kawasaki syndrome. Various bacteria, including TSST-1 producing Staphylococcus aureus, and SPEB and SPEC producing streptococcus have been found to be indicative of the pathological condition. Also described is a Kawasaki syndrome implicated isolate of S. aureus, and therapeutic methodologies for preventing treating the condition. These involve the administration of anti-TSST-1 agents which are not gamma globulin.

REFERENCES:
Boventre et al., "Toxic of Recombinant Toxic Shock Syndrome Toxin 1 and Mutant Toxins Produced by Staphyloccus aureus in a Rabbit Infection Model of Toxic Shock Syndrome", Infect. & Immun. 61(3): 793-799 (Mar. 1993).
Rich et al., "Intravaenous IgG: Supertherapy for Superantigens?", J. Clin. Invest. 91: 378 (1993).
Takei et al., "Intravenous Immunoglobulin Contains Specific Antibodies Inhibitory to Activation of T Cells by Staphylococcal Toxin Superantigens", J. Clin. Invest. 91: 602-607 (Feb. 1993).
Bonventre et al., "Neutralization of Toxic Shock Syndrome Toxin-1 by Monoclonal Antibodies in vitro and in vivo", Infect. & Immun. 56(1): 135-141 (Jan. 1988).

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