Method for treating ischemic oranoxic insult to neurons employin

Details Method for treating ischemic oranoxic insult to neurons employin Method for treating ischemic oranoxic insult to neurons employin

1993-03-15

1994-01-25

Hollrah, Glennon H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514921, 546133, A61K 3144

Patent

active

052815994

ABSTRACT:
A method is provided for treatment of neuronal insult, such as caused by lack of oxygen, which neurons are prone to Parkinsonian degeneration by administering an ATP-sensitive potassium channel blocker, such as a sulfonyl urea, for example, tolbutamide.

REFERENCES:
patent: 3825665 (1974-07-01), Weber et al.
patent: 3932658 (1976-01-01), Weber et al.
patent: 4931464 (1990-06-01), Grover et al.
patent: 5166207 (1993-07-01), Smith
patent: 5215985 (1993-06-01), Murphy et al.
Sturgess, N., et al, "The sulphonylurea receptor may be an ATP-sensitive potassium channel," Lancet 8453, 474-475 (1985).
Noma, A. (1983), "ATP-regulated K.sup.+ channels in cardiac muscle," Nature 305: 147-148.
Virsolvy-Vergine A., et al, (1988), "An endogenous ligand for the central sulfonylurea receptor," FEBS Letters 242: 65-69.
de Weille, J., et al, "ATP-sensitive K.sup.+ channels that are blocked by hypoglycemia-inducing sulfonylureas in insulin-secreting cells are activated by galanin, a hyperglycemia-inducing hormone," Natl. Acad. Sci. USA 85, 1312-1316 (1988).
Ashcroft, F. M., "Adenosine 5'-triphosphate-sensitive potassium channel," Ann. Rev. Neurosci. 11, 97-118 (1988).
Mourre, C., et al, "Antidiabetic sulfonylureas: Localization of binding sites in the brain and effects on the hyperpolirization induced by anoxia in hippocampal slices," Brain Res. 486: 159-164, (1989).
Hansen et al, "Tolbutamide in the treatment of Parkinson's disease," Danish Medical Bulletin 12 (7): 181-184 (Dec., 1965).
Gates et al, "Use of tolbutamide in paralysis agitans," JAMA., vol. 172, No. 13, pp. 79-82 (1979).
Gillhespy and Paton, British Medical Journal, (1960) 2:1597.

Affiliated with

Also associated with

Rating

Method for treating ischemic oranoxic insult to neurons employin does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for treating ischemic oranoxic insult to neurons employin, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for treating ischemic oranoxic insult to neurons employin will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-727876