Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1993-09-22
1995-09-19
Hollinden, Gary E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514255, 514305, 514592, 514593, 514921, A61K 3155, A61K 3144, A61K 31175
Patent
active
054515807
ABSTRACT:
A method is provided for treatment of neuronal insult, such as caused by lack of oxygen, which neurons are prone to Parkinsonian degeneration by administering an ATP-sensitive potassium channel blocker, such as a sulfonyl urea, for example, tolbutamide.
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Gillhespy and Paton, British Medical Journal, (1960) 2: 1597.
Sturgess, N., et al, "The sulphonylurea receptor may be an ATP-sensitive potassium channel," Lancet 8453, 474-475 (1985).
Noma, A. (1983), "ATP-regulated K.sup.+ channels in cardiac muscle," Nature 305: 147-148.
Virsolvy-Vergine A., et al, (1988), "An endogenous ligand for the central sulfonylurea receptor," FEBS Letters 242: 65-69.
Weille de, J., et al, "ATP-sensitive K.sup.+ channels that are blocked by hypoglycemia-inducing sulfonylureas in insulin-secreting cells are activated by galanin, a hyperglycemia-inducing hormone," Natl. Acad. Sci. USA 85, 1312-1316 (1988).
Ashcroft, F. M., "Adenosine 5'-triphosphate-sensitive potassium channel," Ann. Rev. Neurosci. 11, 97-118 (1988).
Mourre, C., et al, "Antidiabetic sulfonylureas: Localization of binding sites in the brain and effects on the hyperpolirization induced by anoxia in hippocampal slices," Brain Res. 486: 159-164 (1989).
Greenfield Susan A.
Murphy Kerry P. S. J.
E. R. Squibb & Sons Inc.
Hollinden Gary E.
Rodney Burton
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