Method for treating insult to neurons prone to Parkinson's degen

Details Method for treating insult to neurons prone to Parkinson's degen Method for treating insult to neurons prone to Parkinson's degen

1993-09-22

1995-09-19

Hollinden, Gary E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514255, 514305, 514592, 514593, 514921, A61K 3155, A61K 3144, A61K 31175

Patent

active

054515807

ABSTRACT:
A method is provided for treatment of neuronal insult, such as caused by lack of oxygen, which neurons are prone to Parkinsonian degeneration by administering an ATP-sensitive potassium channel blocker, such as a sulfonyl urea, for example, tolbutamide.

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patent: 3932658 (1976-01-01), Weber et al.
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Gillhespy and Paton, British Medical Journal, (1960) 2: 1597.
Sturgess, N., et al, "The sulphonylurea receptor may be an ATP-sensitive potassium channel," Lancet 8453, 474-475 (1985).
Noma, A. (1983), "ATP-regulated K.sup.+ channels in cardiac muscle," Nature 305: 147-148.
Virsolvy-Vergine A., et al, (1988), "An endogenous ligand for the central sulfonylurea receptor," FEBS Letters 242: 65-69.
Weille de, J., et al, "ATP-sensitive K.sup.+ channels that are blocked by hypoglycemia-inducing sulfonylureas in insulin-secreting cells are activated by galanin, a hyperglycemia-inducing hormone," Natl. Acad. Sci. USA 85, 1312-1316 (1988).
Ashcroft, F. M., "Adenosine 5'-triphosphate-sensitive potassium channel," Ann. Rev. Neurosci. 11, 97-118 (1988).
Mourre, C., et al, "Antidiabetic sulfonylureas: Localization of binding sites in the brain and effects on the hyperpolirization induced by anoxia in hippocampal slices," Brain Res. 486: 159-164 (1989).

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