Method for treating insulin resistance with IGF-I

Details Method for treating insulin resistance with IGF-I Method for treating insulin resistance with IGF-I

1995-05-08

1997-03-18

Allen, Marianne P.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514866, A61K 3830

Patent

active

056123124

ABSTRACT:
A method of chronic modification of cell barrier properties by exposing a cell to a modification-effective amount of IGF-I for at least about 7 days wherein the modification effective amount is between about 50 .mu.g/kg and less than about 500 .mu.g/kg is disclosed. Further disclosed is a method of chronic amelioration or reversal of insulin resistance as well as a method of diagnosing and screening for rhIGF-I sensitive cell barrier properties.

REFERENCES:
patent: 4988675 (1991-01-01), Froesch
Schoenle, E. J., et al., "Recombinant human insulin-like growth factor I (rhIGFI) . . . ", Diabetologia, pp. 675-679, 1991.
Usala, Anton-Lewis, et al., "Brief Rpt.: Treatment of Insulin-Resistant Diabetic . . . "; NEJM, vol. 327, No. 12, pp. 853-857, 1992.
Zenobi, Peter, et al., "Insulin-like Growth Factor--I . . . "; J. Clin. Invest., vol. 90, pp. 2234-2241, Dec. 1992.
Zenobi, Peter, et al., "Effects of IGF-I on Glucose Tolerance . . . " J. Clin. Invest., vol. 89, pp. 1908-1913, Jun. 1992.
Schalch, Don S., et al., "Short-term metabolic effects of rhIGF-I". Modern Concepts of IGF, pp. 705-713, 1991.
Elahi, D., et al., "Hemodynamic and Metabolic Responses to Human IGFI . . . "; Modern Concepts of IGF, pp. 219-224, 1991.
Quin, John et al., "Acute Response to IGF-I in a Patient . . . ", Correspondence Section; NEJM, vol. 323, No. 20, pp. 1425-1426, 1990.

Affiliated with

Also associated with

Rating

Method for treating insulin resistance with IGF-I does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for treating insulin resistance with IGF-I, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for treating insulin resistance with IGF-I will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1706371