Method for treating hypoxia-associated ocular complications

Details Method for treating hypoxia-associated ocular complications Method for treating hypoxia-associated ocular complications

1993-06-18

1995-02-14

Fay, Zohreh

Drug, bio-affecting and body treating compositions

Inorganic active ingredient containing

Heavy metal or compound thereof

514912, A61K 3324

Patent

active

053893832

ABSTRACT:
A method of preventing or treating hypoxia-associated ocular complications in a host in need of such prevention or treatment which comprises administering to the eye of the host a prophylactically or therapeutically effective amount of at least two agents selected from the group consisting of a heme oxygenase inducer, a membrane-permeable anti-acidosis buffer, and an osmoprotectant, as well as an aqueous ophthalmic composition useful therefor.

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Clark, M. E., Hinke, J. A. M. and Todd, M. E., Studies on Water in Barnacle Muscle Fibres II. Role of Ions and Organic Solutes in Swelling of Chemically-Skinned Fibres, J. Exp. Biol. (1981) 90, 43-63.
Nahas, Gabriel G., The Pharmacology of Tris (Hydroxymethyl) Aminomethane (Tham), Pharmacol. Rev., 14 (1962), pp. 447-472.
Geroski, et al., Invest. Opthal. Vis. Sci., vol. 34, No. 4, 1404, 1993.
Conners, et al., Invest. Opthal. Vis. Sci., vol. 33, No. 4, 780, 1992.
Nahas, Gabriel G., M.D., Clin. Pharmacol. and Ther., (1963) 4, 784-802.

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