Method for treating hypoxia

Details Method for treating hypoxia Method for treating hypoxia

1989-03-21

1990-04-03

Rollins, John W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

5142242, 5142305, 514247, 514299, A61K 3155, A61K 3154, A61K 31535, A61K 3150

Patent

active

049140949

ABSTRACT:
A method for curing and/or improving hypoxia characterized by administering a compound represented by the general formula (1), ##STR1## said compounds have been known in prior art literatures, for example, as carbostyril derivatives in Japanese Patent Kokai No. 54-160389 (1979), etc., as benzoxazine derivatives in Japanese Patent Kokai No. 59-70675 (1984), and as benzoazepine derivatives in Japanese Patent Kokai No. 57-193461 (1982), and they have been known as central nervous system controlling agents and antihistaminic agents.
The present invention was established on the basis of the findings that the compounds represented by the general formula (1) possess excellent pharmacological activities for curing and/or improving hypoxia and also possess excellent anti-oxidative activities, which could not have been anticipated from the disclosures in the prior art literatures.

REFERENCES:
patent: 4154832 (1979-05-01), Silvestrini
patent: 4734416 (1988-03-01), Banno et al.
Tucker, Agents and Actions, vol. 10, No. 3, Jun. 1980, pp. 207-212.
Larsson et al., Acta Paediatrica Scandinavica, vol. 71, No. 3, May 1982, pp. 399-402.

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