Method for treating hypertonia with N-(2-furfuryl)-4-chloro-5-su

Details Method for treating hypertonia with N-(2-furfuryl)-4-chloro-5-su Method for treating hypertonia with N-(2-furfuryl)-4-chloro-5-su

1979-09-20

1982-04-13

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Polymer from ethylenic monomers only

424 32, 424 33, A61K 922, A61K 932

Patent

active

043247792

ABSTRACT:
A method for treating hypertonia with a preparation of N-(2-furfuryl)-4-chloro-5-sulfamoyl-anthranilic acid having a slightly retarded release, wherein the release of the active substance in vitro, measured in the flow through-cell to Dibbern, is not more than 5% after 1 hour in a buffer solution of pH 1.5 and about 10 to at most 25% of the active substance content after a two-hour treatment in a buffer solution of pH 5.5.

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patent: 3857933 (1974-12-01), Ross et al.
Davis et al. Current Medical Research & Opinion 5(9): 739-742 (1978) Diuretic Effect Of A Combined Preparation of Frusemide and Slow-Release Potassium Chloride.
PDR-1979 33rd Ed. Physicians' Desk Reference, pp. 915-917, "Lasix" (Furosemide).
Merck Index 9th Ed. 1976, entry 4161, "Furosemide" 8th Ed. (1968), p. 477 (Furosemide).
Halebian et al. J. Pharm. Sci. 58(8), 911-929, Aug. 1969, Pharmaceutical Applications of Polymorphism.
Finchor, J. Pharm. Sci. 57(11), 1825-1835, Nov. 1968, Particle Size of Drugs And Its Relationship To Absorption And Activity.
A.M.A. Drug Evaluations 2nd Ed. (1973), pp. 45, 50, 73, 74, 197, 199.
Dibbern et al. Pharmazeutische Zeitung 48: 1848-1853, Dec. 2, 1971, English Translation.

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