Method for treating hot flashes in humans

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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A61K 3140

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active

059625058

ABSTRACT:
This invention is directed to methods for treating hot flashes as a consequence of declining levels of estrogen or androgen in humans. Specifically, the methods of this invention involve the topical administration of glycopyrrolate compounds to humans.

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Atkin and Brown, (1996) "Treatment of Diabetic Gustatory Sweating with Topical Glycopyrrolate Cream" Diabetic Medicine 13:493-494.
Hays, (1978) "The Frey Syndrome: A Review and Double Blind Evaluation of the Topical Use of a New Anticholinergic Agent" The Laryngoscope 88:1796-1824.
Hays et al., (1982) "The Frey Syndrome: A Simple Effective Treatment" Otolaryngol Head Neck Surg 90:419-425.
Goldberg et al., (1994) "Transdermal Clonidine for Ameliorating Tamoxifen-induced Hot Flashes" J. Clin. Onc. 12:155-158.
Loprinzi et al., (1994) "Megestrol Acetate for the Prevention of Hot Flashes" N. Engl. J. Med. 331:347-351.
May and McGuirt, (1989) "Frey's Syndrome: Treatment with Topical Glycopyrrolate" Head & Neck 11:85-89.
Shaw et al., (1997) "A Randomised Controlled Trial of Topical Glycopyrrolate, the First Specific Treatment for Diabetic Gustatory Sweating" Diabetologia 40:299-301.
Stegehuis and Ellis, (1989) "Treatment of Frey's Syndrome (Gustatory Sweating) with Topical Glycopyrrolate: Case Report" NZ Med J. 103(875):479.
Merck Index, Ninth Edition, Merck & Co., Rahway, NJ, p. 583, #4337 (1976).

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