Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1990-12-18
1993-03-23
Robinson, Allen J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514411, 514838, 514894, A61K 3144, A61K 3140
Patent
active
051964376
ABSTRACT:
Macrolide compounds having the structure shown below ##STR1## wherein R.sup.1 is hydroxy or protected hydroxy, R.sup.2 is hydrogen, hydroxy or protected hydroxy, R.sup.3 is methyl, ethyl, propyl or allyl, R.sup.4 is hydroxy, methoxy or oxo, n is 1 or 2 and the symbol of a line and a dotted is a single bond or a double bond, provided that R.sup.2 is not protected hydroxy where R.sup.4 is hydroxy or oxo are used to treat hepatic disease and regenerate liver tissue by facilitating hypertrophy and hyperplasia of hepatocytes.
REFERENCES:
Ochiai, T. et al, Effect of a New Immunosuppressive Agent, FK 506, on Heterotopic Cardiac Allotransplantation in the Rat, Trans Proc 19:1284-86 (1987).
Starzl, T. E., et al. FK 506 for Liver, Kidney, and Pancreas Transplantation, Lancet 2:1000-1004 (1989).
Inagaki, K. et al, Effects of FK 506 and 15-Deoxyspergualin in Rat Orthotopic Liver Transplantation, Transplant Proceedings 21(1):1069-1071 (1989).
Mazzaferro V. et al, Studies of the Hepatotrophic Qualities of FK 506 and CyA, Transplantation Proc. 22(1 Suppl 1) (1990), pp. 93-95.
The Lancet, (1989), vol. II, pp. 1248-1249, "Augmentation of Rat Liver Regeneration by FK 506 Compared with Cyclosporin", A. Francavilla et al.
Francavilla Antonio
Starzl Thomas E.
Todo Satoru
Fujisawa Pharmaceutical Company, Ltd.
Hollinden Gary E.
Robinson Allen J.
LandOfFree
Method for treating hepatic diseases and regenerating liver tiss does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for treating hepatic diseases and regenerating liver tiss, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for treating hepatic diseases and regenerating liver tiss will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1351974