Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-11-14
1996-08-27
Killos, Paul J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
A01N 4316
Patent
active
055501532
ABSTRACT:
Successful treatment of adult canine heartworm disease (dirofilaria immitis) has been very difficult to achieve. Presently, only one drug is approved for this application by the Counsel of the American Veterinary Medical Association and the Executive Committee of the American Heartworm Society. This drug is thiacetarsimide, an intravenously administered and arsenic-derived compound which has proven moderately efficacious at destroying adult heartworms which are responsible for producing the adverse physiological effects that characterize dirofilaria immitis. Thiacetarsimide is known to induce a host of possible adverse side-effects including anaphylactic shock, liver disease, kidney disease and patient mortality. It has been found that ivermectin, one of a broad class of antiparasiticidal avermectins, is efficacious in destroying both adult and immature heartworms in canines when administered in an effective dose. As compared to thiacetarsimide-based regimes, methods employing ivermectin are efficacious yet less expensive and more convenient for treating canines afflicted with adult heartworms.
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