Method for treating glaucoma by the topical administration of se

Details Method for treating glaucoma by the topical administration of se Method for treating glaucoma by the topical administration of se

1984-05-29

1985-12-17

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514533, 514538, 514539, 514542, 514913, A61K 31275, A61K 31235, A61K 3744

Patent

active

045593590

ABSTRACT:
A method for the treatment of glaucoma or lowering intraocular pressure in a mammal, involving topically administering to the eye of such mammal a selectively metabolized beta-blocking compound of the formula: ##STR1## wherein Ar may be substituted or unsubstituted aromatic, Y may be a straight or branched carbon chain or aralkyl, R may be lower alkyl, lower alkenyl, lower alkynyl, aryl, or aralkyl, and x is an integer from 1 to about 3; or a pharmaceutically acceptable salt thereof. Because of a relatively long duration of action of such compounds in ocular fluids and a relatively short duration of action in the systemic circulation, such compounds are useful for the treatment of excessive intraocular pressure without substantial systemic effects.

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