Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai
Patent
1984-06-11
1986-03-25
Robinson, Douglas W.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ester doai
514533, 514534, 514535, 514538, 514539, 514540, 514542, 514544, 514913, A61K 31275, A61K 31235, A61K 3124
Patent
active
045784035
ABSTRACT:
A method for the treatment of glaucoma or lowering intraocular pressure in a mammal, involving topically administering to the eye of such mammal a selectively metabolized beta-blocking compound of the formula ##STR1## wherein R may be lower alkyl, lower alkynyl aryl, or aralkyl; A may be a direct bond, lower alkylenyl, or lower alkenyl; x may be an integer from 1 to 3; Ar may be substituted or unsubstituted aromatic; R.sub.1 may be lower alkyl, lower hydroxy alkyl, lower alkenyl, lower alkynyl, or aralkyl; and pharmaceutically accepted salts thereof. Because of a relatively long duration of action of such compounds in ocular fluids and a relatively short duration of action in the systemic circulation, such compounds are useful for the treatment of excessive intraocular pressure without substantial systemic side effects.
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American Hospital Supply Corporation
Robinson Douglas W.
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