Method for treating glaucoma by the topical administration of se

Details Method for treating glaucoma by the topical administration of se Method for treating glaucoma by the topical administration of se

1982-12-13

1985-02-26

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560 67, 560110, 560 70, 560 64, C07C 6976, A01N 3710, D01K 31235

Patent

active

045019126

ABSTRACT:
A method for the treatment of glaucoma or lowering intraocular pressure in a mammal, involving topically administering to the eye of such mammal a selectively metabolized beta-blocking compound of the formula ##STR1## wherein R may be lower alkyl, lower hydroxyalkyl, lower alkynyl, aralkyl, or an ester-containing group and Ar may be substituted or unsubstituted aromatic; or a pharmaceutically acceptable salt thereof. Because of a relatively long duration of action of such compounds in ocular fluids and a relatively short duration of action in the systemic circulation, such compounds are useful for the treatment of excessive intraocular pressure without substantial systemic effects.

REFERENCES:
Buechi, O. Metal CA, vol. 68, (1968), 76664u.

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