Method for treating fungal infections with amphotericin B/choles

Details Method for treating fungal infections with amphotericin B/choles Method for treating fungal infections with amphotericin B/choles

1989-03-08

1991-07-16

Peselev, Elli

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 65, 536 168, 536 185, A61K 3170, C07H 100

Patent

active

050325825

ABSTRACT:
An amphotericin B composition containing particles of amphotericin B and cholesterol sulfate, in a molar ratio of between about 1:1 to 1:4. The particles, when stored in lyophilized form and reconstituted in an aqueous suspension, have particle sizes predominantly between aobut 100-400 nm. The composition formed at a molar ratio of about 1:1 amphotericin B:cholesterol sulfate has stable particle sizes in an aqueous suspension over a several-day storage period. The composition is significantly less toxic and more effective in treating fungal infections than prior amphotericin B formulations.

REFERENCES:
patent: 4468513 (1984-08-01), Kirst et al.
patent: 4822777 (1989-04-01), Abra

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