Drug – bio-affecting and body treating compositions – Inorganic active ingredient containing – Heavy metal or compound thereof
Patent
1990-09-14
1992-04-07
Waddell, Frederick E.
Drug, bio-affecting and body treating compositions
Inorganic active ingredient containing
Heavy metal or compound thereof
424639, 424641, 424644, 424646, 424651, 424654, 514 52, 514185, A61K 3324, A61K 3332, A61K 3170, A61K 31555
Patent
active
051026708
ABSTRACT:
The invention relates to a method for treating or preventing ocular swelling and corneal-conjunctival inflammation. This is accomplished by administering to the eye of a subject, either before or after exposure to an ocular swelling stimulus, an amount of a heme oxygenase inducing agent sufficient to increase levels of heme oxygenase in the eye and thereby to reduce or to regulate the amount of 12(R) hydroxyeicosatetraenoic and 12(R) DiHETE acids present. Particularly preferred agents include stannous compounds, such as SnCl.sub.2, other metals, heme derivatives and Vitamin B12. These compounds may be administered in various forms.
REFERENCES:
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Sacerdoti et al., Science, 243: 388-390 (1-20-89).
Masferrer et al., Inv. Ophthal & Vis. Sci., 30(3): 454-460 (Mar. 1989).
Masferrer et al., Inv. Ophthal & Vis. Sci., 31(3): 535-539 (Mar. 1990).
Chemical Abstract, 109:27622m (1988), Zhuang.
Chemical Abstract, 100:186402u (1984), McCarty.
Abraham Nader G.
Dunn Michael W.
Levere Richard D.
Schwartzman Michal L.
Fay Zohreh A.
Waddell Frederick E.
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