Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1995-02-27
2000-01-11
Davenport, Avis M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 13, 514 14, 514 15, A61K 3800, A61K 3802, C07K 500, C07K 700
Patent
active
060136286
ABSTRACT:
A method is provided for treating diseases and conditions of the eye which include scarring and proliferation of fibroblasts. The invention includes a method for treating proliferative vitreoretinopathy. The invention also includes a method for treating glaucoma. One embodiment of the method includes administering to the eye an amount effective for treating such a condition of a polypeptide. The polypeptide includes a sequence of at least about 5 amino acids corresponding substantially to an amino acid sequence from within the 33 kD fragment of the A chain of fibronectin, within the G domain of the A chain of laminin, or within the NC1 domain of the .alpha.2 chain of type IV collagen. Another embodiment of the method, which includes administering to the eye an amount of conjugate including the polypeptide and a carrier molecule conjugate, is also disclosed.
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Agarwal Anita
Balles Mark
Furcht Leo T.
Gregerson Dale S.
Murali Shobana
Davenport Avis M.
Regents of the University of Minnesota
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