Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1983-09-14
1985-12-24
Daus, Donald G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
544392, 544393, A61K 31495, C07D24104
Patent
active
045606862
ABSTRACT:
Compounds of the formula ##STR1## (wherein R.sub.1 is a lower alkyl group, R.sub.2, R.sub.3 and R.sub.4, which may be the same or different, represent a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, a hydroxyl group, a trifluoromethyl group or a lower alkoxycarbonyl group; two adjacent groups of R.sub.2, R.sub.3 and R.sub.4 may combine to form a methylenedioxy group; n is an integer of 2 to 6) or salts thereof, are disclosed.
These compounds are useful as agents for treating circulatory diseases because they have hypotensive action and are capable of increasing the cerebral blood flow, decreasing the heart rate and suppressing ventricular arrhythmia due to myocardial ischemia.
REFERENCES:
De Antoni, Chem. Abst., vol. 74 (1971).
De Antoni et al., Chem. Abstracts, vol. 78:58460b.
Nagano et al., Chem. Abstract, vol. 100:6547p.
Hata Shun-ichi
Kubodera Noboru
Matsunaga Isao
Nabata Hiroyuki
Nagano Hiroyuki
Chugai Seiyaku Kabushiki Kaisha
Daus Donald G.
Shen Cecilia
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