Method for treating asthma using optically pure (R)-albuterol

Details Method for treating asthma using optically pure (R)-albuterol Method for treating asthma using optically pure (R)-albuterol

1993-12-07

1994-11-08

Henley, III, Raymond J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

514826, A61K 31135

Patent

active

053627555

ABSTRACT:
The optically pure R(-) isomer of albuterol, which is substantially free of the S(+) isomer, is a potent bronchodilator for relieving the symptoms associated with asthma in individuals. A method is disclosed utilizing the optically pure R(-) isomer of albuterol for treating asthma while minimizing the side effects associated with chronic administration of racemic albuterol.

REFERENCES:
R. T. Brittain et al., Br. J. Pharmacol., 48:144-147 (1973).
C. J. Hawkins and G. T. Klease, J. Med. Chemistry, 16(7):856-857 (1973).
D. Hartley and D. Middlemiss, J. Med. Chemistry, 14(9):895 (1971).
C. K. Buckner and P. Abel, J. Pharmacol. Exp. Ther., 189(3):616-625 (1974).
Tan et al., "Analysis of Salbutomol Enantiomers in Human Urine by Chiral High Performance Liquid Chromatography and Preliminary Studies Related to the Stereoselective Disposition Kinetics in Man", J. Chromatogr., 422, 187-95 (1987).
Chemical Abstracts 89:123259m (1978).

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