Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2005-05-12
2011-10-04
Saoud, Christine J (Department: 1647)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C530S399000
Reexamination Certificate
active
08030274
ABSTRACT:
The present invention relates an agent comprising FGF2 (Fibroblast Growth Factor-2 or basic Fibroblast Growth Factor (bFGF)) as an effective ingredient for treatment or prevention of Asthma and Chronic Obstructive Pulmonary Disease (COPD). Also, The present invention relates Th1 asthma and COPD mouse animal model induced by Ovalbumin and double strand RNA. The therapeutic agent comprising FGF2 of the present invention can be used for treatment or prevention for airway fibrosis, airway inflammation, airway hyperresponsiveness, airway remodeling, asthma and COPD. Also, Th1 asthma and COPD mice animal model induced by Ovalbumin and double strand RNA can be used for development of therapeutic agent for asthma and COPD.
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Redington, et al., Basic Fibroblast Growth Factor in Asthma: Measurement in Bronchoalveolar Lavage Fluid Basally and Following Allergen Challenge, Journal of Allergy and Clinical Immunology, 107(2): 384-387, 2001.
Hoshino, et al., Expression of Vascular Endothelial Growth Factor, Basic Fibroblast Growth Factor, and Angiogenin Immunoreactivity in Asthmatic Airways and its Relationship to Angiogenesis, Journal of Allergy and Clinical Immunology, 107(2):295-301, 2001.
Kang Soo Hyung
Kim Byong Moon
Kim Yoon-Keum
Son Miwon
Dong-A Pharmaceutical Co., Ltd.
Lucas & Mercanti LLP
Saoud Christine J
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