Method for treating and preventing heart failure and ventricular

Details Method for treating and preventing heart failure and ventricular Method for treating and preventing heart failure and ventricular

1997-12-08

1999-09-07

Henley, III, Raymond

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514317, 514562, 514561, 514454, A61K 31495, A61K 31445, A61K 31195, A61K 3135

Patent

active

059487801

ABSTRACT:
Matrix metalloproteinase inhibitors are useful for preventing and treating heart failure, and ventricular dilatation in mammals.

REFERENCES:
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Webb, et al., "Time Dep. Chgs . . . ", Circ. vol. 92, No. 8, 1995, p. 3433.
Weber et al., "Inadequate Coll. Tethers . . . " Amer. Heart J., vol. 116, No. 6, Part 1, pp. 1641-1646.
Tyagi et al., "Role of Extracellular . . . " Dept. Int. Med., 1995, pp. 73-80.
Armstrong et al., "Struc. Remodel . . . ", Can J Cardiol, vol. 10, No. 2, 1994, pp. 214-220.
Janicki et al., "Myocard. Coll. Remod . . . ", Brazil J Med Biol Res., vol. 25, No. 10, 1992, pp. 975-982.

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