Drug – bio-affecting and body treating compositions – Solid synthetic organic polymer as designated organic active... – Polymer from ethylenic monomers only
Patent
1995-06-05
1999-10-26
Azpuru, Carlos A.
Drug, bio-affecting and body treating compositions
Solid synthetic organic polymer as designated organic active...
Polymer from ethylenic monomers only
424 7835, 424423, 424427, 424430, 424434, 424436, 424441, 424450, 5147724, 526286, 526287, A61K 3174, A61K 31785, A61K 31795, A61K 4732
Patent
active
059723289
ABSTRACT:
Therapeutic compounds and methods for inhibiting amyloid deposition in a subject, whatever its clinical setting, are described. Amyloid deposition is inhibited by the administration to a subject of an effective amount of a therapeutic compound comprising an anionic group and a carrier molecule, or a pharmaceutically acceptable salt thereof, such that an interaction between an amyloidogenic protein and a basement membrane constituent is inhibited. Preferred anionic groups are sulfonates and sulfates. Preferred carrier molecules include carbohydrates, polymers, peptides, peptide derivatives, aliphatic groups, alicyclic groups, heterocyclic groups, aromatic groups and combinations thereof.
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Kisilevsky Robert
Szarek Walter
Weaver Donald
Azpuru Carlos A.
Queen's University at Kingston
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