Method for treating alcoholic liver disease

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

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514 53, 514893, A61K 3170

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active

059523093

ABSTRACT:
A method for the inhibition and amelioration of alcholic liver disease in a mammal in need of such treatment by administering novel analogs of Lipid A which act as endotoxin antagonists. These antagonists compounds are found to inhibit the swift increase in alcohol metabolism which typically accompanies ingestion of alcohol and which may lead to the pathophysiological abnormalities associated with alcoholic liver disease.

REFERENCES:
patent: 5413785 (1995-05-01), Nanji
patent: 5530113 (1996-06-01), Christ et al.
Nolan, J. P. Immunological Investigations 1989, 18, 325-327. Month not available.
Nolan, J. P. Hepatology Nov. 1989, 10, 887-889.
Adachi et al. Hepatology Aug. 1994, 20, 453-460.
Adachi et al., Gastroenterology, 108:218-224, 1995.
Adachi et al., J. Hepatol., 20: 453-460, Aug. 1994.
Bone, Chest, 100:802-808, Sep. 1991.
Casteleijn et al., J. Bio. Chem., 263:2699-2703, Feb. 1988.
DeCarli et al., J. Nutr., 91:331-336, Mar. 1967.
Decker et al., Cells of the Hepatic Sinusoid, pp. 171-175, 1989.
Felver et al. Alcohol Clin. Exp. Res., 14:255-259, Mar./Apr. 1990.
Freudenberg et al., British J. of Exp. Path. 63:56-64, 1982.
Galanos et al., Proc. Nat'l. Acad. Sci., 76:5939-5943, Nov. 1979.
Goto et al., J. Pharmacol. Exp. Ther., 267:1264-1268, 1993.
Grynkiewicz et al., J. Bio. Chem., 260:3440-3450, Mar. 1985.
Hijioka et al., Mol. Pharmacol., 41:435-440, 1992.
Iwaki et al., Cells of the Hepatic Sinusoid, pp. 351-352, 1989.
Karck et al., Cells of the Hepatic Sinusoid, pp. 210-211, 1989.
Knecht et al., Mol. Pharmacol., 47:1028-1034, 1995.
Lahnborg et al., Scand. J. Gastroent., 16:481-489, 1981.
Laskin, Cells of the Hepatic Sinusoid, pp. 284-287, 1989.
Lelbach, Acta Hepatospenol., 13:321-349, Nov./Dec. 1966.
Martinez et al., Alcohol, 9:455-458, 1992.
Marzi et al., Transplant Proc., 22:2004-2005, Aug. 1990.
Mathison et al., J. Immunol., 123:2133-2143, Nov. 1979.
Mendelson et al., Anns. NY Acad. Sci., 133:828-845,1966.
Monden et al., Res. Exp. Med., 191:177-187, 1991.
Nanji et al., Ame. J. Pathol., 142:367-373, Feb. 1993.
Nolan, Hepatology, 1:458-465, 1981.
Pertoft et al., Cell Separation, 4:1-24, 1987.
Porta et al., Lab Invest., 18:352-364, 1968.
Rose et al., Inf. and Immun., 63:833-839, Mar. 1995.
Ruiter et al., Lab Invest., 45:38-45, 1981.
Shiratori et al., Cells of the Hepatic Sinusoid, pp. 313-318, 1989.
Thurman et al., Proc. 78th Falk Symposium, pp. 185-203, 1995.
Thurman et al., Molecular Pharmacol., 12:156-166, 1975.
Ueno et al., Cells of the Hepatic Sinusoid, 2:293-296, 1989.
Van Bossuyt et al., Cell Tiss. Res., 251:205-215, 1988.
Vogel et al., J. Immunol., 124:2004-2009, Apr. 1980.
Wisse et al., Cells of the Hepatic Sinusoid, 2:1-8, 1989.
Yamada et al., Liver, 11:220-224, 1991.
Yuki et al., Biochem. J., 186:119-126, 1980.

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