Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai
Reexamination Certificate
2008-06-24
2008-06-24
Marschel, Ardin (Department: 1614)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ester doai
C514S520000, C514S555000, C514S562000
Reexamination Certificate
active
07390833
ABSTRACT:
The present invention relates to methods of treating ADAMTS-5-associated diseases and particularly osteoarthritis comprising administering an agent capable of modulating ADMATS-5 activity to a subject afflicted with the disease. The agent is preferably a biaryl sulfonamide compound. The invention is based, in part, on the discovery that transgenic animals that do not express functional ADAMTS-5 show a reduction in the degree of osteoarthritis after the induction of osteoarthritis as compared to WT animals. Furthermore, the ADAMTS-5 transgenic animals have reduced aggrecanase activity in articular tissue as compared to WT animals. These animals are good models for ADAMTS-5-associated diseases, and for screening of drugs useful in the treatment and/or prevention of these diseases. There are no other animal models in which the deletion of the activity of a single gene is capable of abrogating the course of osteoarthritis. Accordingly, these animals also show that osteoarthritis can be prevented and/or treated by administering to a subject an ADAMTS-5 inhibitory agent and particularly an agent capable of inhibiting the aggrecanase activity of ADAMTS-5.
REFERENCES:
patent: 6376665 (2002-04-01), Duan
patent: 6391610 (2002-05-01), Apte et al.
patent: 6451575 (2002-09-01), Arner et al.
patent: 6566381 (2003-05-01), Cheng et al.
patent: WO 03-066822 (2003-08-01), None
Collins-Racie et al., 2004, Matrix Biol. 23:219-230.
Glasson et al., 2004, Arthritis & Rhuem, 50:2547-2558.
Clements et al., 2003, Arthritis & Rhuem 48:3452-3463.
Somerville et al., 2003, Biol. Chem. 278:9503-9513.
Little et al., 2002, Arthritis & Rhuem 46:124-129.
Bau et al., 2002, Arthritis & Rhuem 46:2648-2657.
Tortorella et al., 2002, Matrix Biol. 21:499-511.
Rodriguez-Manzaneque et al., 2002, Biochem Biophys. Res. Commun. 293:501-508.
Yamanashi et al., 2002, J. Immunol. 168:1405-1412.
Tortorella et al., 2001, Osteoarthritis Cartilage 9:539-552.
Chambers et al., 2001, Arthritis & Rhuem 44:1455-1465.
Curtis et al., 2000, J. Biol. Chem 275:721-724.
Tortorella et al., 2000, J. Biol. Chem. 275:18566-18573.
Kuno et al., 2000, FEBS Letters 478:241245.
M.A. Abramov, W. Dehaen, B. D'hooge, M.L. Petrov, S. Smeets, S. Toppet and M. Voets Tetrahedron, 2000, 56, 3933-3940.
Tortorella et al., 1999, Science 284:1664-1666.
Abbaszade et al., 1999, J. Biol. Chem. 274:23443-23450.
Lohmander, Neame and Sandy, 1993, Arthritis & Rhuem 36:1214-1223.
Farndale et al., 1986, Biochim Biophys Acta 883:173-177.
Sandy et al., 1991, J. Biol. Chem. 266:8683-8685.
Database HCAPLUS on STN (DN 134:305005, Biorg. & Med. Chem. Let., 2001, 11(2)91-94, abstract).
Database HCAPLUS on STN (DN 137:183746, J. Biol. Chem., 2002, 277(25)22201-208, abstract).
Database HCAPLUS on STN (DN 139:175864, WO 2003066822).
Glasson Sonya
Morris Elisabeth A.
Xiang Jason Shaoyun
Fitzpatrick ,Cella, Harper & Scinto
Lewis Amy A
Marschel Ardin
Wyeth
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