Method for transforming human B lymphocytes

Details Method for transforming human B lymphocytes Method for transforming human B lymphocytes

1991-11-08

1993-06-29

Nucker, Christine M.

Chemistry: molecular biology and microbiology

Treatment of micro-organisms or enzymes with electrical or...

Modification of viruses

435 696, 435 7021, 4351723, 43524027, 5303881, 530808, 530809, 935 93, 935100, C12N 1501, C12N 1502

Patent

active

052234177

ABSTRACT:
Disclosed herein is a method for transforming human B-cells preferably by infecting them with Epstein-Barr virus followed by transforming the Epstein Barr virus infected cells with an activated human ras gene. The transformed cells are useful for producing human monoclonal antibodies either without further manipulation or after fusion with antibody-secreting cells.

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