Method for transferring genes to the heart using AAV vectors

Details Method for transferring genes to the heart using AAV vectors Method for transferring genes to the heart using AAV vectors

1995-09-27

2000-12-19

Yucel, Remy

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

435455, 435456, 435325, 4353201, A61K 3170

Patent

active

061627968

ABSTRACT:
The invention relates to the use of adeno-associated virus vectors for the transfer of genes to the heart and vasculature. The vector preferably contains a gene encoding a protein which improves heart and vascular function during heart failure. In a specific embodiment, the vector is introduced into the heart and vasculature via a catheter, with the aid of fluoroscopy. The method and vectors for use therein provide for safe and stable gene expression of the transferred genes.

REFERENCES:
patent: 5139941 (1992-08-01), Muzyczka et al.
patent: 5252479 (1993-10-01), Srivastava
patent: 5580766 (1996-12-01), Mason et al.
patent: 5797870 (1998-08-01), March et al.
Marshall, E. Science. vol. 269, pp. 1050-1055, Aug. 25, 1995.
Crystal, R. Science, vol. 270, pp. 404-410, 1995.
Jolly, D. Cancer Gene Therapy. vol. 1, No. 1, pp. 51-64, 1994.
Orkin et al. NIH Report, Dec. 5, 1995.
Verma et al. Nature. vol. 389, pp. 239-242, Sep. 18, 1997.
Editorial. Nature Biotechnology, vol. 15, Sep. 1997.
Gura, T. Science. vol. 270, pp. 575-577, Oct. 27, 1995.
Roush, W. Science. vol. 276, pp. 1192-1193, May 23, 1997.
Gyurko et al. (1995) FASEB J. 9:A330.
Kaplitt et al. (1995) In: Viral Vectors. Chpt. 12:1-18, Academic Press, NY.
Kourtis et al. (1995) Modern Pathol. 8:33A.
Barr et al. (1994) Gene Therapy 1:51-8.
Duboc et al. (1994) Circulation 90:I-517 (No. 2784).
French et al. (1994) Circulation 90:I-517 (No. 2785).
Gnatenko et al. (1994) Blood 84:Abst.2949.
Guzman et al. (1994) Proc. Natl. Acad. Sci. USA 91:10732-6.
Kaplitt et al. (1994) Nature Genetics 8:148-54.
Nabel et al. (1994) Cardiovascular Res. 28:445-55.
Russell et al. (1994) Proc. Natl. Acad. Sci. USA 91:8915-9.
Sawa et al. (1994) Circulation 90:I-46 (No. 0239).
Flotte et al. (1993) J. Biol. Chem. 268:3781-90.
Flotte et al. (1993)Proc. Natl. Acad. Sci. USA 90:10613-7.
Flotte et al. (1992) Am. J. Respir. Cell. Mol. Biol. 7:349-56.
March et al. (1992) Eur. Heart J. 13:218.
Muro-Cacho et al. (1992) J. Immunoother. 11:231-7.
Nahreini et al. (1992) Gene 119:265-72.
Walsh et al. (1992) Proc. Natl. Acad. Sci. USA 89:7257-61.
Samulski et al. (1989) J. Virol. 63:3822-8.
McLaughlin et al. (1988) J. Virol. 62:1963-73.
Vastava et al. (1983) J. Virol. 45:555-64.

Affiliated with

Also associated with

Rating

Method for transferring genes to the heart using AAV vectors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for transferring genes to the heart using AAV vectors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for transferring genes to the heart using AAV vectors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-271411