Method for transdifferentiating mesenchymal stem cells into...

Details Method for transdifferentiating mesenchymal stem cells into... Method for transdifferentiating mesenchymal stem cells into...

2003-08-14

2010-06-08

Paras, Jr., Peter (Department: 1632)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Method of regulating cell metabolism or physiology

C435S455000, C435S368000, C424S093200

Reexamination Certificate

active

07732203

ABSTRACT:
This inventive discloses a method for transdifferentiating mesenchymal stem cells into neuronal cells, which comprises increasing the level of a basic helix-loop-helix (bHLH) transcription factor in the mesenchymal stem cells, said cells being useful in cell therapy or gene therapy for treating brain neurological diseases such as Parkinson's disease, Alzheimer disease, Hungtington's disease, amyotrophic lateral sclerosis, cerebral paralysis and brain ischemia; and spine disfunction caused by a traumatic injury.

REFERENCES:
patent: 7547545 (2009-06-01), Prockop et al.
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Elwood et al., 1998, Blood, vol. 91, pp. 3756-3765.
1 page printout from medterms.com.
Exhibit 1: Phinney and Prockop, Stem Cells, 25:2896-2902, 2007.
Exhibit 2: Wiese et al, Cellular and Molecular Life Sciences, 61:2510-2522, 2004.
Exhibit 3: Tondreau et al, Differentiation, 72:319-326, 2004.
Exhibit 4: Lu et al., J. Neurosci, Res., 77:174-191, 2004.
Exhibit 5: Neuhuber et al., J. Neurosci, Re., 77:192-204, 2004.

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