Method for total synthesis of ecteinascidins and...

Details Method for total synthesis of ecteinascidins and... Method for total synthesis of ecteinascidins and...

2007-04-25

2010-10-05

Wilson, James O (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C544S342000, C544S338000, C544S153000, C544S343000, C544S377000

Reexamination Certificate

active

07807833

ABSTRACT:
An intermediate compound for total synthesis of ecteinascidins comprising, a compound represented by general formula 2 having thioether group at C4 site, and the substituent R2of N12site is trichloroethoxicarbonyl (Troc) to which various substituents can be introduced by mild condition, further having 10 members ring structure which can be converted to a ring of other numbered members.

REFERENCES:
Endo, “Total Synthesis of Ecteinascidin 743”, J. Am. Chem. Soc. 2002, vol. 124, 6552-6554.
Corey, “Enantioselective Total Synthesis of Ecteinascidin 743”, J. Am. Chem. Soc. 1996, vol. 118, 9202-9203.
Tohma, “Synthesis of Optically Active alpha-Arylglycines: Stereoselective Mannich-Type Reaction with a New Chiral Template”, Synlett 2001, No. 7, 1179-1181.
Endo, “Synthetic Study on Ecteinascidin 743 Starting From D-Glucose”, Synlett 1999, No. 7, 1103-1105.
Hinterding, “Synthesis and In Vitro Evaluation of the Ras Farnesyltransferase Inhibitor Pepticinnamin E”, Angew. Chem. Int. Ed. 1998, 37, No. 9 1236-1239.

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