Method for total synthesis of ecteinascidins and...

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C544S148000, C544S338000, C544S153000, C544S343000, C544S377000, C544S344000, C544S342000, C549S213000, C549S214000

Reexamination Certificate

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07820838

ABSTRACT:
An intermediate compound for total synthesis of ecteinascidins comprising, a compound represented by general formula 2 having thioether group at C4 site, and the substituent R2of N12site is trichloroethoxycarbonyl (Troc) to which various substituents can be introduced by mild condition, further having 10 members ring structure which can be converted to a ring of other numbered members.

REFERENCES:
Endo, “Total Synthesis of Ecteinascidin 743”, J. Am. Chem. Soc. 2002, vol. 124, 6552-6554.
Corey, “Enantioselective Total Synthesis of Ecteinascidin 743”, J. Am. Chem. Soc. 1996, vol. 118, 9202-9203.
Tohma, “Synthesis of Optically Active alpha-Arylglycines: Stereoselective Mannich-Type Reaction with a New Chiral Template”, Synlett 2001, No. 7, 1179-1181.
Endo, “Synthetic Study on Ecteinascidin 743 Starting From D-Glucose”, Synlett 1999, No. 7, 1103-1105.
Hinterding, “Synthesis and In Vitro Evaluation of the Ras Farnesyltransferase Inhibitor Pepticinnamin E”, Angew. Chem. Int. Ed. 1998, 37, No. 9 1236-1239.

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