Method for topical inhibition of the metabolic activity of cytoc

Details Method for topical inhibition of the metabolic activity of cytoc Method for topical inhibition of the metabolic activity of cytoc

1994-10-14

1997-08-19

Spivack, Phyllis G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514171, 514252, 514399, A61K 3157, A61K 31415, A61K 31495, A61K 3813

Patent

active

056588810

ABSTRACT:
This invention relates to a method for the inhibition of the metabolic activity of cytochrome P450 enzymes by topical administration of a cytochrome P450 inhibitor. Particularly, this invention relates to a method for inhibition of the metabolic activity of cytochrome P450 in the lungs or nasal membranes of a patient by topical administration of a cytochrome P450 inhibitor by inhalation. The effect of the inhibition of cytochrome P450 activity is the increase in the localized concentration of administered or endogenous steroids normally metabolized by the cytochrome P450. This increased concentration of steroid results in the more effective treatment of inflammatory conditions of the lungs and nasal membranes.

REFERENCES:
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patent: 5081114 (1992-01-01), Gourvest et al.
patent: 5215965 (1993-06-01), Lezdey et al.
M. Harman, L. Hendeles, Clinical Relevance of the Interaction of Theophylline with Diltiazen or Nifedipine, Feb., 1989.
D. Sesardic, et al., Furafylline is a Potent and Selective Inhibitor of Cytochrome P-450 1A2 in Man, Jun., 1990.
T. Iwana, et al., Effects of NZ-107 on Airway Inflammation and Cell Activation in Guinea Pigs, Apr., 1993.
Vanden Boesche et al., Br. J. Clin. Pract. Symp. Suppl., (1990 Sep.) 71, pp. 41-46, Abstract.

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