Method for therapy of liver tumors

Details Method for therapy of liver tumors Method for therapy of liver tumors

2007-05-22

2007-05-22

Azpuru, Carlos A. (Department: 1615)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

Reexamination Certificate

active

10343602

ABSTRACT:
A method for regional administration of preparations during the therapy of liver tumor, comprising administering a preparation into a branch of the portal vein with the simultaneous occlusion of afferent and efferent lobe vessels (branches of the portal vein proximal the place of puncture, branches of the hepatic artery and lobar hepatic vein) for 5–15 minutes.During catalytic therapy, it is preferable to use Teraphtalum as the preparation and to administer ascorbic acid after termination of occlusion.During photodynamic therapy, it is preferable to use photosens as the preparation and to carry out irradiation of the tumor after 10–35 minutes.This method of administration provides for the predominant accumulation of the preparations in the target lobe (tumor carrier lobe) of the liver, their low penetration into the systemic blood flow, which makes it possible to reduce the dose of the preparation and its general toxicity.

REFERENCES:
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patent: 2065734 (1996-08-01), None
Liu et al, “Intra-Operative Laser Induced Photodynamic Therapy in the Treatment of Experimental Hepatic Tumors” Abstract, European Journal of gastroenterology & Hepatology, (Nov. 1995), vol. 7, No. 11, pp. 1073-1080.
Rayner, A.A. et al., “Total hepatic arterial perfusion after occlusion of variant lobar vessels: implications for hepatic arterial chemotherapy”, Surgery. Jun. 1986.
Nagasue N. et al. “Hepatic dearterialization for nonrespectable primary and secondary tumors of the liver”, Cancer Dec. 1976.
van Hillegersberg, R. et al., “Interstitial photodynamic therapy in a rat liver metastasis model”, Cancer, 1992.
Carlsson, G., et al., “Estimation of Liver Tumor Volume Using Different Formulas-An Experimental Study in Rats”, Cancer Research Clinical Oncology, 1983, pp. 20-23.
Sofina, E.P., et al., Experimental assessment of antitumor preparations in USSR and USA, 1980, pp. 71-106.

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