Method for therapeutically treating abnormal cells expressing a

Details Method for therapeutically treating abnormal cells expressing a Method for therapeutically treating abnormal cells expressing a

1987-03-23

1989-08-29

Moskowitz, Margaret

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

530351, 530395, 530806, 530808, 530828, 4352402, 4352401, 435243, 435244, 424 851, 424 858, 935101, 935105, 935107, 935109, A61K 4505, A61K 3526, C12N 500, C12N 502

Patent

active

048615897

ABSTRACT:
The present invention provides a lymphocyte-mediated immunotherapy for the treatment of human or animal subjects afflicted with abnormal or tumor cells which express a MHC Class II antigen on their surface. The method utilizes inducer T-cell clones or lines having a demonstrable specificity for an identifiable antigen. These T-cells are activated in-vivo to express cytolytic and therapeutic activity against the abnormal or tumor cells in the subject.

REFERENCES:
patent: 4681760 (1987-07-01), Fathman
patent: 4690915 (1987-09-01), Rosenberg
patent: 4695459 (1987-09-01), Steinman et al.
Zier, J. Imm. Methods, 84, 73-84 (1985).
Clayberger et al, J. Exp. Med., 157, 1906-19 (1983).
Damle et al, J. Immunol., 132(2), 649-650 (1984).
Chizzolini et al, J. Immunol., 137(3), 1022-8 (1986) (Aug.).
Ettinghausen et al, J. Immunol., 135(5), 3623-35 (1985).
DeKruyff et al, J. Immunol., 135(4), 2243-8 (1985).
Reinherz et al, J. Immunol., 126(1), 67-70 (1981).
Damle et al, J. Exp. Med., 158, 159-73 (1983).
Schmitt et al, Eur. J. Immunol., 12, 849-54, (1982).
Umetsu et al, Eur. J. Immunol., 15, 356-61, (1985).
Puri et al, Eur. J. Immunol., 15, 362-8, (1985).
Blue et al, PNAS (USA), 82, 8178-82, (1985).
DeKruyff et al, J. Immunol., 136(2), 446-51, (1985).
Damle et al, J. Immunol., 133(3), 1235-40, (1984).
Tite et al, J. Immunol., 135(1), 25-33, (1985).
Dialynas et al, J. Immunol., 131(5), (1983).
Rosenberg et al, Science, 233, 1318-22, (1986).
Ettinghausen et al, J. Immunol., 135(2), 1488-97, (1985).
Ju et al, J. Immunol, 134(6), 3722-30, (1985).
"Cellular Immunology", vol. 2, Weir et al., (Eds.), pp. 71.1-71.7 and 75.1-75.7, (1986).
Umetsu et al., J. Immunol. 140:4211-4216 (1988).
Lanzavecchia et al., J. Exp. Med. 167:345-352 (1988).

Affiliated with

Also associated with

Rating

Method for therapeutically treating abnormal cells expressing a does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for therapeutically treating abnormal cells expressing a , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for therapeutically treating abnormal cells expressing a will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2236984