Method for the use of [ 11 C] carbon monoxide in labeling...

Details Method for the use of [ 11 C] carbon monoxide in labeling... Method for the use of [ 11 C] carbon monoxide in labeling...

2005-12-14

2009-12-01

Sullivan, Daniel M (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

C560S130000, C204S157970, C422S159000, C422S186000

Reexamination Certificate

active

07626052

ABSTRACT:
Methods and reagents for photo-initiated carbonylation with carbon-isotope labeled carbon monoxide using alkyl/aryl iodides with alcohols pretreated by a base are provided. The resultant carbon-isotope labeled esters are useful as radiopharmaceuticals, especially for use in Positron Emission Tomography (PET). Associated kits for PET studies are also provided.

REFERENCES:
patent: WO 02102711 (2002-12-01), None
Kiyoto Nagahara, Ilhyong Ryu, Mitsuo Komatsu, and Noboru Sonoda Radical Carboxylation: Ester Synthesis from Alkyl Iodides, Carbon Monoxide, and Alcohols under Irradiation Conditions J. Am. Chem. Soc. 1997, 119, 5465-5466.
IB2005/00373 WO Search report with written opinion dated May 4, 2006.
Kiyoto Nagahara, et.al. “Radical Carboxylation” Ester Synthesis from Alkyl Iodides, Carbon Monoxide, and Alcohols under Irradiation Conditions J. Am. Chem. Soc. vol. 119, 1997 pp. 5465-5466.
T. Hihlberg, et.al. “[11C] Carbon Monoxide in Synthesis of 11C-labelled Esters Using Padlladium-Mediated Reactions with Organo Halides” J. Labelled CPD. Radiopharm, vol. 44, 2001, pp. S990-S992.
Jan-Olov Thorell et.al. “Preparation of [11C]diethyl Oxalate and [11C]oxalica acid and Demonstration of their use in the Synthesis of [11C]-2,3-dihydroxyquinoxaline” J. Labelled CPD. Radiopharm., vol. 33, 1993, pp. 995-1005.
Meldrum B. Winstead: “Relationship of Molecular Structure to in vivo Scintigraphic Distribution of Carbon-11 Labeled Compounds. 4. carbon-11 Labeled Mendelonitriles, Mandelic Acids and Their Ester” J. Med. Chem., vol. 21, No. 2, 1978, pp. 215-217.

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