Method for the treatment or prevention of restenosis associated

Details Method for the treatment or prevention of restenosis associated Method for the treatment or prevention of restenosis associated

1996-12-30

2000-02-01

Yu, Mickey

Surgery

Miscellaneous

Methods

514535, A61B 1900

Patent

active

06019104&

ABSTRACT:
A method for treating patients to inhibit restenosis associated with coronary intervention, which comprises administering compounds of the class of aminobenzoic acids, specifically 2-(3,4-dimethoxy-cinnamoyl)-aminobenzoic acid or its pharmaceutically acceptable salt at a dosage which is sufficient to maintain the plasma concentration at about 100.mu. molar for a period of time of less than three months.

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British Journal of Pharmacology 118, 915-922 (1996) "Anti proliferative and c-myc mRNA Suppressive effects of tranilaston . . . ".
Can. J. Physiol. Pharmacol. 74, 80-84 (1996) "Inhibitory effects of tranilast on proliferation, migration, and collagen synthesis of human vascular . . . ".
Atherosclerosis 118, 213-221 (1995) "Inhibition of PDGF-and TGF-Bi-induced collagen synthesis migration, and proliferation by tranilast in vascular smooth muscle cells from . . . ".
Ohyouyakuri 50 (5), 539-548 (1995) "Suppressive effect of an anti-allergic Drug, Tranilast, on the Vascular Intimal . . . ".
European Journal of Pharmacology, 295, 221-227 (1996) "Tranilast suppresses intimcl hyperplasia . . . ".
Jpn. J. Pharmacol. 70, 321-327 (1996) "Tranilast Suppresses Intimcl Hyperplasia in the balloon injury model and cuff . . . ".

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