Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2006-04-25
2006-04-25
Ketter, James (Department: 1636)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C530S350000
Reexamination Certificate
active
07033996
ABSTRACT:
The present invention provides a method for treating diseases caused by either an excess or diminution of Vitamin D3. It provides pharmaceutical compositions for the treatment of such diseases and the methods by which these compositions are to be used. Also provided are methods for testing the activity of both 24(OH)ase and CCAATT/Enhancer Binding Protein β (C/EBPβ), as well as, for testing the effect of a compound on 24(OH)ase and C/EBPB activity activity. In particular embodiments, a method is provided for reducing the risk of hypercalcemia when administering 1,25(OH)2D3or its analogs for the treatment of vitamin D diseases. Methods for both enhancing and diminishing 24(OH)ase activity are also provided.
REFERENCES:
patent: 2003/0166586 (2003-09-01), Sealy
Baran et al., “Rapid actions of 1α, 25-dihydroxyvitamin D3on Ca2+and phospholipids in isolated rat liver nuclei”, Feb. 1989 259(1) :205-208.
Chen et al., “Cloning of the human 1α, 25-dihyroxyvitamin D-3 24-hydroxylase gene promoter and identification of two vitamin D-responsive elements”, Biochimica et Biphysica Acta 1995 1263 : 1-9.
Civitelli et al., “Nongenomic Activation of the Calcium Message System by Vitamin D Metabolites in Osteoblast-like Cells”, Endocrinology 1990 127 (5) :2253-2262.
Feldman et al., “Rapid Biological Responses Mediated by 1α, 25-Dihydroxyvitamin D3:A Case Study of Transcaltachia (Rapid Hormonal Stimulation of Intestinal Calcium Transport)”, 1997 Chapter 15 233-256.
Kerry et al., “Transcriptional Synergism between Vitamin D-responsive Elements in the Rat 25-Hydroxyvitamin D324-Hydroxylase (CYP24) Promoter”, J. Biol. Chem. 1996 271 (47) :29715-29721.
Lieberherr et al., “A Functional Cell Surface Type Receptor Is Required for the Early Action of 1,25-Dihydroxyvitamin D3on the Phosphoinositide Metabolism in Rat Enterocytes”, J. Biol. Chem/ 1989 264 (34) :20403-20406.
Lowe et al., “Vitamin D-Mediated Gene Expression”, Critical Reviews in Eukaryotic Gene Expression 1992 2 (1) :65-109.
Minghetti et al., “1, 25 (OH)2receptors: gene regulation and genetic circuitry”, FASEB 1988 2 (15) : 3043-3053.
Nemere et al., “Identification of a Specific Binding Protein for 1α, 25-Dihydroxyvitamin D3in Basal-Lateral Membranes of Chick Intestinal Epithelium and Relationship to Transcaltachia”, J. Biol. Chem. 1994 269 (38) :23750-23756.
Nemere et al., “Calcium Transport in Perfused Doudena from Normal Chicks:Enhancement within Fourteen Minutes of Exposure to 1, 25- Dihyroxyvitamin D3”, Endocrinology 1984 115 (4) : 1476-1483.
Norman et al., “The Vitamin D Endocrine System:Steroid Metabolism, Hormone Receptors, and Biological Response (Calcium Binding Proteins)”, Endocrine Reviews 1982 3 (4) :331-366.
Ohyama et al., “Identification of a Vitamin D-responsive Element in the 5′-Flanking Region of the Rat 25-Hydroxyvitamin D324-Hydroxylase Gene”, J. Biol. Chem. 1994 269 (140:10545-10550.
Pike, J. Wesley, “Vitamin D3Receptors : Structure and Function in Transcription”, Annu. Rev. Nutr. 1991 11: 189-216.
Tsutsumi et al., “Effect of 1, 25-dihydroxyvitamin D3on phospholipid composition of rat renal brush border membrane”, Am. J. Physiol. 1985 294:F117-F123.
Zierold et al., “Identification of a vitamin D-response element in the rat calcidiol (25-hydroxyvitamin D3) 24-hydroxylase gene”, Proc. Natl. Acad. Sci. USA 1994 91:900-902.
Garvey Tara L
Ketter James
Licata & Tyrrell P.C.
University of Medicine & Dentistry of New Jersey
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