Drug – bio-affecting and body treating compositions – Conjugate or complex of monoclonal or polyclonal antibody,...
Patent
1995-06-05
1997-11-04
Feisee, Lila
Drug, bio-affecting and body treating compositions
Conjugate or complex of monoclonal or polyclonal antibody,...
4241811, 4241381, 435183, 5303877, 5303888, 5303917, A61K 3942, C07K 1628, C07K 1900
Patent
active
056836945
ABSTRACT:
A method for treatment of tumors to which antibody A5B7 binds is disclosed. A5B7 is a monoclonal antibody which binds to carcinoembryonic antigen. The method comprises administering to a host in need of such treatment an effective amount of a system which comprises a conjugate comprising: antibody A5B7 or a humanized version of A5B7 linked to an enzyme selected from the group consisting of carboxypeptidase G2 (CPG2), nitroreductase, a human enzyme, a non-human enzyme rendered non-immunogenic in man and a humanized catalytic antibody; and a prodrug convertible under the influence of the conjugate into a cytotoxic drug.
REFERENCES:
patent: 4185111 (1980-01-01), Ducep et al.
patent: 4564675 (1986-01-01), Kurabayashi et al.
patent: 4675187 (1987-06-01), Konishi et al.
patent: 4762707 (1988-08-01), Jansen et al.
I. Hellstrom et al., "Monoclonal Mouse Antibodies Raised against Human Lung Carcinoma", Cancer Research, 46, pp. 3917-3923 (Aug. 1986).
G. W. Philpott et al., "Affinity Cytotoxicity of Tumor Cells with Antibody-Glucose Oxidase Conjugates, Peroxidase, and Arsphenamine", Cancer Research, 34, pp. 2159-2164 (Sept 1974).
I. Hellstrom et al., "Monoclonal Antibodies to Two Determinants of Melanoma-Antigen p97 Act Synergistically in Complement-Dependent Cytotoxicity", The Journal of Immunology, 127(1), pp. 157-160 (Jul. 1981).
V. J. Stella et al., "Prodrugs: A Chemical Approach to Targeted Drug Delivery", Directed Drug Delivery, pp. 247-267 (1985).
T. Nishiyama et al., "Antineoplastic Effects in Rats of 5-Fluorocytosine in Combination with Cytosine Deaminase Capsules", Cancer Research, 45, pp. 1753-1761 (Apr. 1985).
D. E. V. Wilman, "Prodrugs in Cancer Chemotherapy", Biochemical Society Transactions, 14, pp. 375-382, (615th Meeting, Belfast 1986).
P. J. O'Dwyer et al., The New England Journal of Medicine, 312, pp. 692-700 (Mar. 14th, 1985).
A. P. Albino et al., "Heterogeneity in Surface Antigen and Glycoprotein Expression of Cell Lines Derived from Different Melanoma Metastases of the Same Patient", J. Exp. Med., 154, pp. 1764-1778 (Dec. 1981).
R. Arnon et al., "In Vitro and In Vivo Efficacy of Conjugates of Daunomycin with Anti-Tumor Antibodies", Immunological Rev., 62, pp. 5-27, (1982).
K. D. Bagshawe, "Antibody Directed Enzymes Revive Anti-Cancer Prodrugs Concept", Br. J. Cancer, 56, pp. 531-532 (Nov. 1987).
K. D. Bagshawe, "A Novel Approach to Prodrug Activation Using a Monoclonal Antibody Conjugated to Carboxypeptidase G2", from the Third International Conference on Monoclonal Antibody Immunoconjugates for Cancer, Abstract #43, p. 70 (San Diego, Feb. 4-6, 1988).
R. W. Baldwin et al., "Design and Therapeutic Evaluation of Monoclonal Antibody 791T/36-Methotrexate Conjugates" in Monoclonal Antibodies and Cancer Therapy, pp. 215-231 (Alan R. Liss, Inc. 1985).
R. W. Baldwin et al., "Monoclonal Antibodies in Cancer Treatment", Lancet, pp. 603-605 (Mar. 15, 1986).
R. W. Baldwin et al. "Monoclonal Antibody Drug Conjugagates for Cancer Therapy", Monoclonal Antibodies in Cancer: Advances in Diagnosis and Treatment, Jack A. Roth (ed)., pp. 215-257 (Futura Publishing Co., 1986).
J. P. Brown et al., "Structural Characterization of Human Melanoma-Associated Antigen p97 with Monoclonal Antibodies", J. Immunology, 127 (2), pp. 539-546, (Aug. 1981).
E. A. Clark et al., "Role of the Bp35 Cell Surface Polypeptide in Human B-Cell Activation", Proc. Natl. Acad. Sci., 82, pp. 1766-1770 (Mar. 1985).
S. T. Crooke et al. (eds.) Anthracyclines: Current Status and New Developments, Academic Press, cover pages and table of contents, (New York, 1980).
R. A. DeWeger et al., "Eradication of Murine Lymphoma and Melanoma Cells by Chlorambucil-Antibody Complexes", Immunological Rev., 62, pp. 29-45 (1982).
M. J. Embleton et al., "Antibody Targeting of Anti-Cancer Agents", Monoclonal Antibodies for Cancer Detection and Therapy, R. W. Baldwin and V.S. Byers (eds.), pp.321-322 (Academic Press, 1985).
M. J. Embleton, "Targeting of Anti-Cancer Therapeutic Agents by Monoclonal Antibodies", Biochemical Society Transactions, 14, pp. 393-395 (615th Meeting, Belfast 1986).
N. Endo et al. "In Vitro Cytotoxicity of a Human Serum Albumin-Medicated Conjugate of Methotrexate with Anti-MM46 Monclonal Antibody", Cancer Research, 47, pp. 1076-1080 (Feb. 15th, 1987).
P. J. Fraker et al., "Protein and Cell Membrane Iodinations with a Sparingly Soluble Chloroamide, 1,3,4, 6-Tetrachloro-3a,6a-Diphenylglycoluril", Biochem. Bio-physical Research Comm., 80(4), pp. 849-857 (Feb. 1978).
I. Hellstrom et al., "Antitumor Effects of L6, an IgG2a Antibody that Reacts with Most Human Carcinomas", Pro.Natl.Acad.Sci.U.S.A, 83, pp. 7059-7063 (Sep. 1986).
I. Hellstrom et al., "Antibodies for Drug Delivery", Controlled Drug Delivery (2nd ed.), Robinson and Lee (eds.), pp. 638-642 (1987).
P. L. Ipata et al., "Baker's Yeast Cytosine Deaminase. Some Enzymic Properties and Allosteric Inhibition by Nucleosides and Nucleotides", Biochemistry, 10(23) pp. 4270-4276 (1971).
T. Katsuragi et al., "Affinity Chromatography of Cytosine Deaminase from Escherichia coli with Immobilized Pyrimidine Compounds", Agric. Biol. Chem., 50(7), pp. 1713-1719 (1986).
J. M. Lambert et al., "Purified Immunotoxins That Are Reactive with Human Lymphoid Cells", J. Biol. Chemistry 260 (22), pp. 12035-12041 (1985).
J. P. Mach et al., "Improvement of Colon Carcinoma Imaging: From Polyclonal Anti-CEA Antibodies and Static Photoscanning to Monoclonal Fab Fragments and ECT", Monoclonal Antibodies for Cancer Detection and Therapy, R. W. Baldwin et al (eds), pp. 53-64, Academic Press (1985).
R. B. McComb et al. (eds)., Alkaline Phosphatase, Plenum Press, Chapters 4, 5, 6 and 11 (New York 1979).
R. G. Melton et al., "In Vivo Localization of Carboxypeptidase G2:Antibody Conjugates in Human Colon Carinoma Xenografts", from the Third International Conference on Monoclonal Antibody Immunoconjugates for Cancer Abstract #83, p. 110 (San Diego, Feb. 4-6, 1988).
S. Monfardini et al. (eds), Manual of Cancer Chemotherapy, Third Edition, UICC Technical Reports Series, 56, Table of Contents, pp. 1-230 (Geneva 1981).
F. L. Moolten et al., "Antibodies Conjugated to Potent Cytotoxins as Specific Antitumor Agents", Immunological Rev., 62, pp. 47-73 (1982).
K. Ohkawa et al., "Selective in Vitro and In Vivo Growth Inhibition Against Human Yolk Sac Tumor Cell Lines by Purified Antibody Against Human .alpha.-Fetoprotein Conjugated with Mitomycin C via Human Serum Albumin", Cancer Immunol. Immunother, 23, pp. 81-86 (1986).
C. W. Parker et al., "Enzymatic Activation and Trapping of Luminol-Substituted Peptides and Proteins. A Possible Means of Amplifying the Cytotoxicity of Anti-Tumor Antibodies", Pro.Nat.Acad.Sci. USA, 72(1), pp. 338-342 (1975).
G. W. Philpott et al., "Selective Iodination and Cytotoxicity of Tumor Cells with an Antibody-Enzyme Conjugate", Surgery, 74(1), pp. 51-58 (1973).
G. W. Philpott et al., "Selective Cytotoxicity of Hapten-Substituted Cells with an Antibody-Enzyme Conjugate", The Journal of Immunology, 111(3), pp. 921-929 (1973).
M. J. Robins et al., "Nucleic Acid Related Compounds. 16. Direct Fluorination of Uracil Nucleotides Using Trifluoromethyl Hypofluorite", Can. J. Chem., 53, pp. 1302-1306 (1975).
G. F. Rowland et al., "Drug Localisation and Growth Inhibition Studies of Vindesine-Monoclonal Anti-CEA Conjugates in a human Tumour Xenograft", Cancer Immunol Immunother, 21, pp. 183-187 (1986).
F. Searle et al., "Antibody Carboxpeptidase G2 Conjugates as Anti-Tumor Agent", Tumor Biology, 6(4), pp. 355 (1985).
F. Searle et al., "The Potential of Carboxypeptidase G2 Antibody Conjugates as Anti-Tumor Agents. I. Preparation of Antihuman Chorionic Gonadotrophin-Carboxypeptidase G2 and Cytotoxicity of the Conjugate Against JAR Choriocarcinoma Cells In Vitro", Br. J. Cancer, 53, p. 377-384 (1986).
W. T. Shearer et al., "Cytotoxicity with Antibody-Glucose Oxidase Conjugates Specific for a Human Colonic Cancer and Carcinoembryonic Antigen", Int. J. Cancer, 14, pp. 539-547 (1974).
V. J. Stella et al., "Prodrugs Do They Have Advantages in Clinical Practice?", Drugs, 29, pp. 455-473 (1985).
W. A
Bagshawe Kenneth D.
Rogers Gordon T.
Sharma Surinder K.
Cancer Research Campaign Tech. Ltd. & Zeneca Ltd.
Feisee Lila
LandOfFree
Method for the treatment of tumors with conjugated antibody A5B7 does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for the treatment of tumors with conjugated antibody A5B7, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for the treatment of tumors with conjugated antibody A5B7 will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1830944