Method for the treatment of retroviral diseases such as acquired

Details Method for the treatment of retroviral diseases such as acquired Method for the treatment of retroviral diseases such as acquired

1994-07-28

1997-02-18

Clardy, S. Mark

Drug, bio-affecting and body treating compositions

Inorganic active ingredient containing

Heavy metal or compound thereof

424604, 424609, 424702, A61K 3324, A61K 3342, A61K 3304

Patent

active

056039638

ABSTRACT:
A method of treating retroviral diseases such as AIDS in an infected host is provided. The method comprises administering a therapeutically effective amount of at least one (pseudo)halogen complex of gold(I) in a pharmaceutically acceptable carrier. The (pseudo)halogen complex in gold(I) can be chosen from the group consisting of:

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Aurothiolates Inhibit HIV-1 Infectivity by Gold(1) Ligand Exchange with a Component of the Virion Surface, Okada et al., Virology 192, pp. 631-642 (1993).
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Graham et al, "Medicinal Chemistry of Gold", Agents Actions Suppl., 44(Variability in Response to Anti-Rheumatic Drugs), 209-17 (1993).
Dubhghaill et al, "Gold Complexes in cancer chemotheraphy", Met. Complexes Cancer Chemother., 221-48; Editor: Keppler (1993).

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