Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai
Patent
1995-02-17
1997-03-11
Goldberg, Jerome D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ester doai
514309, 514312, A61K 31235, A61K 3147
Patent
active
056101856
ABSTRACT:
The present invention relates to a method of treating hyperproliferative epithelial lesions by topical administration. The method prevents growth and actively cross-links these aberrant cells, thereby killing the cells. The present invention is useful in control and prevention of hyperproliferative epithelial disorders, such as HPV-infected cell lesions, actinic keratosis, melanomas, and malignant and pre-malignant carcinomas.
REFERENCES:
patent: 4421927 (1983-12-01), Picart
patent: 4833240 (1989-05-01), Maignan et al.
patent: 4925877 (1990-05-01), Umezawa et al.
patent: 5360815 (1994-11-01), Fortin, et al.
Umezawa, et al., 1990 "Inhibition of epidermal growth factor-induced DNA synthesis by tyrosine kinase inhibitors" FEBS Lett. 260(2):198-200.
Umezawa, et al., 1992 "Inhibition of epidermal growth factor receptor functions by tyrosine kinase inhibitors in NIH3T3 cells" FEBS Letts. 314(3):289-292.
Hori, et al., 1992 "Inhibition of tyrosine Kinase and src oncogene functions by stable erbstatin analogues" J. Antibiotics, 45(2):280-282.
Burke, 1994 "Protein-tyrosin kinase: potential targets for anticancer drug development" Stem Cells 12:1-6.
Markovits, et al., 1994 "Inhibition of DNA topoisomerases I and II and induction of apoptosis by erbstatin and tyrphostin derivatives" Biochem. Pharm. 48(3):549-560.
Burke, Jr. Terrence R.
Stanwell Caroline
Yuspa Stuart H.
Goldberg Jerome D.
The United States of America as represented by the Department of
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