Method for the treatment of heart failure

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C424S602000, C424S678000, C424S682000

Reexamination Certificate

active

10467459

ABSTRACT:
A combination therapy for the treatment of heart failure, particularly acute heart failure, comprises administering a combination of levosimendan or a pharmaceutically acceptable salt thereof and a calcium ion source and/or an intracellular calcium increasing agent to a patient. The combination shows a synergistic effect even at doses having no effect if administered alone.

REFERENCES:
patent: 4529602 (1985-07-01), Wada et al.
patent: 4745130 (1988-05-01), Wurtman
patent: 4971982 (1990-11-01), Attwood et al.
patent: 5120738 (1992-06-01), Ikawa et al.
patent: 5424428 (1995-06-01), Nore et al.
patent: 5512571 (1996-04-01), Nore et al.
patent: 5569657 (1996-10-01), Nore et al.
patent: 5998458 (1999-12-01), Bristow
patent: 6030943 (2000-02-01), Crumb et al.
patent: 6323226 (2001-11-01), Delgado et al.
patent: 6355269 (2002-03-01), Backman et al.
patent: 6448248 (2002-09-01), Amberg et al.
patent: 6531458 (2003-03-01), Larma et al.
patent: 6730673 (2004-05-01), Backstrom et al.
patent: 0 411 766 (1991-02-01), None
patent: 0 565 546 (1995-03-01), None
patent: WO92/12135 (1992-07-01), None
patent: WO93/21921 (1993-11-01), None
patent: WO98/27070 (1998-06-01), None
patent: WO99/16443 (1999-04-01), None
patent: WO99/55337 (1999-11-01), None
patent: WO99/66912 (1999-12-01), None
Handbook of Pharmaceutical Excipients, published 1986 by American Pharmaceutical Association (DC), pp. 26-33.
Cecil Textbook of Medicine, Goldman et al. (editors), 21stEdition, vol. 1, published 2000, pp. 215-225.
Handbook of Pharmaceutical Excipients, published by the American Pharmaceutical Association, 1986, pp. 36-40 and 44.
F. Guideri et al., “Calcium infusion induces myocardial ischaemia in patients with coronary artery disease by a mechanism possibly adenosine mediated”, European Heart Journal, vol. 15, pp. 1158-1163 (1984).
Nicolai Gruhn et al., “Coronary Vasorelaxant Effect of Levosimendan, a New Inodilator with Calcium-Sensitizing Properties”, Journal of Cardiovascular Pharmacology, vol. 31, pp. 741-749 (1998).
Heimo Haikala et al., “The role of cAMP- and cGMP-dependent protein kinases in the cardiac actions of the new calcium sensitizer, levosimendan”, Cardiovascular Research, vol. 34, pp. 536-546 (1997).
Herwig Köppel et al., “Minimal Effects of Levosimendan on Coronary Artery Smooth Muscle Tone”, Cardiovascular Drugs and Therapy vol. 13, pp. 357-358 (1999).
Derwent Abstract of WO 98/27070 (2003).
J. Lilleberg et al., “Effects of a new calcium sensitizer, levosimendan, on haemodynamics, coronary blood flow and myocardial substrate utilization early after coronary artery bypass grafting,” European Heart Journal (1998) 19: 660-668.
Stig Sundberg et al., “Hemodynamic and Neurohumoral Effects of Levosimendan, a New Calcium Sensitizer, at Rest and During Exercise in Healthy Men,” Am. J. Cardiol (1995) 75:1061-1066.
Esa-Pekka Sandell et al., “Pharmacokinetics of Levosimendan in Healthy Volunteers and Patients with Congestive Heart Failure,” Journal of Cardiovascular Pharmacology, 26 (Suppl. 1): S57-S62 (1995).
J. Lilleberg et al., “Dose-Range Study of a New Calcium Sensitizer, Levosimendan, in Patients with left Ventricular Dysfunction”, Journal of Cardiovascular Pharmacology, 26 (Suppl. 1): S63-S69 (1995).
Lynette R. Moser et al., “The use of calcium salts in the prevention and management of verapamil-induced hypotension”, American Chemical Society (2002)—Abstract 133:159.
William G. Hughes et al., “Should Calcium Be Used in Cardiac Arrest?,” The American Journal of Medicine, (1986) 81:285-296.

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