Method for the treatment of endotoxic shock in a mammal

Drug – bio-affecting and body treating compositions – Lymphokine

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A61K 39395

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051241471

ABSTRACT:
The invention is a method of treating endotoxic shock in a mammal which comprises administering to the mammal a therapeutically effective amount of an antagonist to Platelet Activating Factor in combination with a therapeutically effective amount of one or more monoclonal or polyclonal antibodies directed toward either Tumor Necrosis Factor .alpha., Interleukin-1.beta., Gamma Interferon, or bacterial cell wall lipopolysaccharides.

REFERENCES:
Tracey et al. Science vol. 234, Oct. 24, (1986) pp. 470-474.
Beutler et al. Science vol. 229 (1985) Aug. 30, pp. 869-871.
Terashita et al. Europ. J. of Pharmacology (1985) vol. 109, pp. 257-261.

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