Method for the treatment of diabetes

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for...

Reexamination Certificate

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Reexamination Certificate

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07122357

ABSTRACT:
The use of physiologically acceptable enzyme mixtures having lipolytic, proteolytica and amylolytic activity, of microbial or animal origin, preferably digestive enzyme mixtures such as pancreatin or digestive enzyme mixtures containing pancreatin, for the treatment of diabetes. The invention also relates to the production of pharmaceutical compositions suitable for such treatment. A preferred variant of the invention relates to use of this enzyme mixture having lipolytic, proteolytic and amylolytic activity, especially digestive enzyme mixtures such as pancreatin or digestive enzyme mixtures containing pancreatin, for the adjuvant treatment of type I or type II diabetes mellitus.

REFERENCES:
patent: 3803305 (1974-04-01), Thuillier
patent: 2512746 (1977-04-01), None
patent: 4203315 (1992-08-01), None
patent: 908352 (1982-02-01), None
Nakamura et al., Pancreas, vol. 16, No. 3, 329-36.
Fallis et al., Annals of Surgery, Oct. 1948, pp. 639-667.
Murlin et al., Proceedings of the Society for Experimental Biology and Medicine, vol. 14, pp. 8-9, 1917.
M. Delhaye, “Comparative Evaluation of a High Lipase Pancreatic Enzyme Preparation and a Standard Pancreatic Supplement for Treating Exocrine Pancreatic Insufficiency in Chronic Pancreatitis” European Journal of Gastronenterology and Hepatology, 1996.
I. Simek, “Substitution Therapy in Insufficient External Pancreatic Secretion” Online Medline Database, 1993.
D. D'Costa, “Diabetic Neuropathic Cachexia Associated with Malabsorption” Diabetic Medicine, 1992.
Copy of the International Search Report.
H. P. Klotz, Lyophilized Pancreatic Extract, an Aid in the Treatment of Mild Diabetes, La Nouvelle Presse medicals, Oct. 1975 (in French and English, abstract.
Goodman and Gilman's “The Pharmacological Basis of Therapeutics”, 8thed. Pergamon Press 1990: p. 1471-1477.
Printout of the online “Diabetes Dictionary” of the American Diabetes Association®.

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