Method for the treatment of conditions caused by herpes virus in

Details Method for the treatment of conditions caused by herpes virus in Method for the treatment of conditions caused by herpes virus in

1995-06-07

1998-06-09

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 17, 514 18, 514 9, 530328, 530329, 530330, 530317, A61K 3808, A61K 3800, A61K 3812

Patent

active

057634068

ABSTRACT:
Peptides of the general formula (I): I-A-B-C-D-E-F-G-H-II are disclosed as being active against Herpes virus infections in animals and human beings, wherein A is Ala, Gly, Val or absent; B is Ala, Gly, Val, Ser or absent; C is Ser, Thr or absent; D is Ser, Thr, Ans, Glu, Arg, Ile, Leu or absent; E is Ser, Thr, Asp or absent; F is Thr, Ser, Asn, Gln, Lys, Trp or absent; G is Tyr or absent; H is Thr, Gly, Met, Met(O), Cys, Thr or Gly; I is Cys or absent, and II is Cys, an amide group, substituted amide group, an ester group or absent, wherein the peptides comprise at least 4 amino acids and physiologically acceptable salts thereof.

REFERENCES:
Pert, C. B. Small peptides which inhibit binding to T4 receptors on human T-lymphocytes, inhibition of AIDS virus infection by the peptides, and their use as immunogens. Chem. Abstracts #93418, 1989.
Identification of a Putative Cell Receptor for Human Cytomegalovirus, Adlish et al., Virology 176, 337-345 (1990).
New Methods and Reagents in Organic Synthesis. 55.+ 1 Total Synthesis of Patellamides B and C, Cytotoxic Cyclic Peptides From a Tunicate 1. Their Proposed Structures Should Be Corrected.2, Hamada, et al., Tetrahedron Letters, vol. 26, No. 42, pp. 5155-5158, 1985.
Prodrug derivatives of thyrotropin-releasing hormone and other peptides, Bundgaard, et al., Peptide Drug Delivery, vol. 17, 947-949, (1989).

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