Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heavy metal containing doai
Patent
1992-06-19
1995-01-31
Henley, III, Raymond J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heavy metal containing doai
514500, 514562, A61K 3130, A61K 31195
Patent
active
053859332
ABSTRACT:
A composition and a method for inhibiting cellular proliferation, such as the abnormal cellular proliferation characteristic of cancer cells. The method comprises the administration to a mammal, in particular a human, of an effective amount of S-(methylthio)-DL-homocysteine or S-(methylthio)-L-homocysteine, either simultaneously or sequentially, with an effective amount of a copper chelate such that an effective amount of an inhibitory complex forms in the mammal between the S-(methylthio)-homocysteine and the copper of the cooper chelate. The inhibitory complex is capable of inhibiting the proliferation of cells contacted by the inhibitory complex.
REFERENCES:
patent: 5124351 (1992-06-01), Rabinovitz et al.
Christopherson et al., "Potent Inhibitors of De Novo Pyrimidine and Purine Biosynthesis as Chemotherapeutic Agents," Medicinal Research Reviews, 10 (4): 505-548. 1990.
Livingston et al., "Glutamine Antagonists in Chemotherapy," Adv. Pharmacol. Chemotherap., 8: 57-120. 1970.
Mohindru et al., "2,9-Dimethyl-1, 10-Phenanthroline (Neocuproine): A Potent, Copper-Dependent Cytotoxin With Anti-Tumor Activity," Biochemical Pharmacology, 32 (23): 3627-3632. 1983.
Neil et al., "Studies of the Biochemical Pharmacology of the Fermentation-Derived Antitumor Agent, (.alpha.S, 5S)-.alpha.-Amino-3-Chloro-4, 5-Dihydro-5-Isoxazoleacetic Acid (AT-125)," Adv. Enzyme Regul., 17: 375-398. 1978.
Rabinovitz et al., "Evidence for a Copper:S-(Methylthio)-L-homocysteine Complex as a Glutamine Antagonist of Cytidine Triphosphate Synthesis in L1210 Murine Leukemia Cells," Molecular Pharmacology, 34: 401-406. 1988.
Starkebaum et al., "Endothelial Cell Injury Due to Copper-catalyzed Hydrogen Peroxide Generation from Homocysteine," The Journal of Clinical Investigation, Inc., 77: 1370-1376. 1986.
Fisher Joyce M.
Rabinovitz Marco
Criares T. J.
Henley III Raymond J.
The United States of America as represented by the Department of
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